Sequence Detail

ID/Version

Q60848 Q8VDZ1 Q497T3 Q9CYV7 (UniProt | EBI)

Last sequence update: 2001-03-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Lymphocyte-specific helicase; EC=3.6.4.-;AltName: Full=Proliferation-associated SNF2-like protein;

Provider

SWISS-PROT

Sequence

Polypeptide 821 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Hells	helicase, lymphoid specific	38	104	3	58

Sequence references in MGI

J:32111 Jarvis CD, et al., A novel putative helicase produced in early murine lymphocytes. Gene. 1996 Mar 9;169(2):203-7
J:52084 Geiman TM, et al., Characterization of gene expression, genomic structure, and chromosomal localization of Hells (Lsh). Genomics. 1998 Dec 15;54(3):477-83
J:61948 Geiman TM, et al., Lsh, an SNF2/helicase family member, is required for proliferation of mature T lymphocytes. Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4772-7
J:69100 Raabe EH, et al., An SNF2 factor involved in mammalian development and cellular proliferation. Dev Dyn. 2001 May;221(1):92-105
J:72618 Dennis K, et al., Lsh, a member of the SNF2 family, is required for genome-wide methylation. Genes Dev. 2001 Nov 15;15(22):2940-4
J:76112 Geiman TM, et al., Lsh, a SNF2 family member, is required for normal murine development. Biochim Biophys Acta. 2001 May 3;1526(2):211-20
J:85948 Yan Q, et al., Lsh, a modulator of CpG methylation, is crucial for normal histone methylation. EMBO J. 2003 Oct 1;22(19):5154-62
J:89936 Yan Q, et al., Association of Lsh, a regulator of DNA methylation, with pericentromeric heterochromatin is dependent on intact heterochromatin. Mol Cell Biol. 2003 Dec;23(23):8416-28
J:96925 Fan T, et al., Lsh controls silencing of the imprinted Cdkn1c gene. Development. 2005 Feb;132(4):635-44
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:107145 Sun LQ, et al., Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG. Genes Dev. 2004 May 1;18(9):1035-46
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89