Sequence Detail

ID/Version

Q60841 Q9CUA6 E9PZ78 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Reelin {ECO:0000303|PubMed:7715726}; EC=3.4.21.- {ECO:0000269|PubMed:11689558};AltName: Full=Reeler protein;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 3461 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Reln	reelin	111	250	3	34

Sequence references in MGI

J:24459 D'Arcangelo G, et al., A protein related to extracellular matrix proteins deleted in the mouse mutant reeler [see comments]. Nature. 1995 Apr 20;374(6524):719-23
J:24460 Hirotsune S, et al., The reeler gene encodes a protein with an EGF-like motif expressed by pioneer neurons [see comments]. Nat Genet. 1995 May;10(1):77-83
J:39165 D'Arcangelo G, et al., Reelin is a secreted glycoprotein recognized by the CR-50 monoclonal antibody. J Neurosci. 1997 Jan 1;17(1):23-31
J:41321 Schiffmann SN, et al., Reelin mRNA expression during mouse brain development. Eur J Neurosci. 1997 May;9(5):1055-71
J:44722 Royaux I, et al., Genomic organization of the mouse reelin gene. Genomics. 1997 Dec 1;46(2):240-50
J:54649 Lambert de Rouvroit C, et al., Evolutionarily conserved, alternative splicing of reelin during brain development. Exp Neurol. 1999 Apr;156(2):229-38
J:63408 Yip JW, et al., Reelin controls position of autonomic neurons in the spinal cord. Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8612-6
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:212819 Hiesberger T, et al., Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation. Neuron. 1999 Oct;24(2):481-9
J:248288 Yasui N, et al., Structure of a receptor-binding fragment of reelin and mutational analysis reveal a recognition mechanism similar to endocytic receptors. Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):9988-93
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:313948 Yasui N, et al., Functional importance of covalent homodimer of reelin protein linked via its central region. J Biol Chem. 2011 Oct 7;286(40):35247-56
J:354380 Quattrocchi CC, et al., Reelin is a serine protease of the extracellular matrix. J Biol Chem. 2002 Jan 4;277(1):303-9