Sequence Detail

ID/Version

Q60803 Q62380 B2RPW3 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=TNF receptor-associated factor 3 {ECO:0000312|MGI:MGI:108041}; EC=2.3.2.27;AltName: Full=CD40 receptor-associated factor 1 {ECO:0000303|PubMed:7533327}; Short=CRAF1 {ECO:0000312|MGI:MGI:108041};AltName: Full=CD40-binding prot

Provider

SWISS-PROT

Sequence

Polypeptide 567 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Traf3	TNF receptor-associated factor 3	80	107	3	25

Sequence references in MGI

J:34086 Cheng G, et al., Involvement of CRAF1, a relative of TRAF, in CD40 signaling. Science. 1995 Mar 10;267(5203):1494-8
J:34163 Wang X, et al., A candidate gene for the amnionless gastrulation stage mouse mutation encodes a TRAF-related protein. Dev Biol. 1996 Jul 10;177(1):274-90
J:37065 Xu Y, et al., Targeted disruption of TRAF3 leads to postnatal lethality and defective T-dependent immune responses. Immunity. 1996 Nov;5(5):407-15
J:124329 Xie P, et al., Tumor necrosis factor receptor-associated factor 3 is a critical regulator of B cell homeostasis in secondary lymphoid organs. Immunity. 2007 Aug;27(2):253-67
J:124635 He JQ, et al., Rescue of TRAF3-null mice by p100 NF-kappa B deficiency. J Exp Med. 2006 Oct 30;203(11):2413-8
J:132877 Gardam S, et al., TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor. Immunity. 2008 Mar;28(3):391-401
J:143167 Zarnegar BJ, et al., Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK. Nat Immunol. 2008 Dec;9(12):1371-8
J:143169 Vallabhapurapu S, et al., Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling. Nat Immunol. 2008 Dec;9(12):1364-70
J:144594 Sanada T, et al., FLN29 deficiency reveals its negative regulatory role in the Toll-like receptor (TLR) and retinoic acid-inducible gene I (RIG-I)-like helicase signaling pathway. J Biol Chem. 2008 Dec 5;283(49):33858-64
J:147101 Jabara HH, et al., TRAF2 and TRAF3 independently mediate Ig class switching driven by CD40. Int Immunol. 2009 Apr;21(4):477-88
J:157878 Tseng PH, et al., Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines. Nat Immunol. 2010 Jan;11(1):70-5
J:164781 He JQ, et al., Specificity of TRAF3 in its negative regulation of the noncanonical NF-kappa B pathway. J Biol Chem. 2007 Feb 9;282(6):3688-94
J:166021 Hacker H, et al., Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6. Nature. 2006 Jan 12;439(7073):204-7
J:194553 Hu H, et al., OTUD7B controls non-canonical NF-kappaB activation through deubiquitination of TRAF3. Nature. 2013 Feb 21;494(7437):371-4
J:196439 Chen BB, et al., A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation. Nat Immunol. 2013 May;14(5):470-9
J:208241 Wang Y, et al., The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity. Immunity. 2013 Jul 25;39(1):111-22
J:226812 Lin D, et al., Induction of USP25 by viral infection promotes innate antiviral responses by mediating the stabilization of TRAF3 and TRAF6. Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):11324-9
J:233920 Panda S, et al., Deubiquitinase MYSM1 Regulates Innate Immunity through Inactivation of TRAF3 and TRAF6 Complexes. Immunity. 2015 Oct 20;43(4):647-59
J:245346 Oganesyan G, et al., Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response. Nature. 2006 Jan 12;439(7073):208-11
J:319680 Shinzawa M, et al., Catalytic subunits of the phosphatase calcineurin interact with NF-kappaB-inducing kinase (NIK) and attenuate NIK-dependent gene expression. Sci Rep. 2015 Jun 1;5:10758