Sequence Detail

ID/Version

Q60795 Q3UQK0 (UniProt | EBI)

Last sequence update: 1998-01-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Nuclear factor erythroid 2-related factor 2 {ECO:0000303|PubMed:9240432}; Short=NF-E2-related factor 2 {ECO:0000303|PubMed:9240432}; Short=NFE2-related factor 2 {ECO:0000303|PubMed:9240432};AltName: Full=Nuclear factor, eryth

Provider

SWISS-PROT

Sequence

Polypeptide 597 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nfe2l2	nuclear factor, erythroid derived 2, like 2	184	121	3	131

Sequence references in MGI

J:24214 Chui DH, et al., cDNA cloning of murine Nrf 2 gene, coding for a p45 NF-E2 related transcription factor. Biochem Biophys Res Commun. 1995 Apr 6;209(1):40-6
J:37053 Chan K, et al., NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development. Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13943-8
J:41943 Itoh K, et al., An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem Biophys Res Commun. 1997 Jul 18;236(2):313-22
J:61871 Itoh K, et al., Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev. 1999 Jan 1;13(1):76-86
J:68072 Ramos-Gomez M, et al., From the Cover: Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice. Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3410-5
J:76861 Fahey JW, et al., Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors. Proc Natl Acad Sci U S A. 2002 May 28;99(11):7610-5
J:85958 Cullinan SB, et al., Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Mol Cell Biol. 2003 Oct;23(20):7198-209
J:86392 Wakabayashi N, et al., Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation. Nat Genet. 2003 Nov;35(3):238-45
J:86725 Leung L, et al., Deficiency of the Nrf1 and Nrf2 transcription factors results in early embryonic lethality and severe oxidative stress. J Biol Chem. 2003 Nov 28;278(48):48021-9
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:107804 Thimmulappa RK, et al., Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis. J Clin Invest. 2006 Apr;116(4):984-95
J:108124 Padmanabhan B, et al., Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer. Mol Cell. 2006 Mar 3;21(5):689-700
J:114001 Wang Y, et al., Cloning and characterization of the mouse polyamine-modulated factor-1 (mPMF-1) gene: an alternatively spliced homologue of the human transcription factor. Biochem J. 2001 Oct 15;359(Pt 2):387-92
J:162670 Lau A, et al., A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62. Mol Cell Biol. 2010 Jul;30(13):3275-85
J:172945 Komatsu M, et al., The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nat Cell Biol. 2010 Mar;12(3):213-23
J:218003 Cullinan SB, et al., PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stress. J Biol Chem. 2004 May 7;279(19):20108-17
J:239920 Kobayashi EH, et al., Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription. Nat Commun. 2016 May 23;7:11624
J:240280 Tong KI, et al., Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model. Mol Cell Biol. 2006 Apr;26(8):2887-900
J:241128 Zhou W, et al., ERRbeta: a potent inhibitor of Nrf2 transcriptional activity. Mol Cell Endocrinol. 2007 Nov 15;278(1-2):52-62
J:247330 Suzuki T, et al., Stress-sensing mechanisms and the physiological roles of the Keap1-Nrf2 system during cellular stress. J Biol Chem. 2017 Oct 13;292(41):16817-16824
J:279942 Kobayashi A, et al., Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. Mol Cell Biol. 2004 Aug;24(16):7130-9
J:279945 Sanghvi VR, et al., The Oncogenic Action of NRF2 Depends on De-glycation by Fructosamine-3-Kinase. Cell. 2019 Aug 8;178(4):807-819.e21
J:279946 Cullinan SB, et al., The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase. Mol Cell Biol. 2004 Oct;24(19):8477-86