Sequence Detail

ID/Version

Q60764 Q3UY92 Q7TQE4 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=E3 ubiquitin-protein ligase makorin-3; EC=2.3.2.27;AltName: Full=RING-type E3 ubiquitin transferase makorin-3 {ECO:0000305};AltName: Full=Zinc finger protein 127;

Provider

SWISS-PROT

Sequence

Polypeptide 544 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mkrn3	makorin, ring finger protein, 3	13	99	3	12

Sequence references in MGI

J:54555 Jong MT, et al., Imprinting of a RING zinc-finger encoding gene in the mouse chromosome region homologous to the Prader-Willi syndrome genetic region. Hum Mol Genet. 1999 May;8(5):795-803
J:85656 Lee S, et al., Prader-Willi syndrome transcripts are expressed in phenotypically significant regions of the developing mouse brain. Gene Expr Patterns. 2003 Oct;3(5):599-609
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:304791 Li C, et al., MKRN3-mediated ubiquitination of Poly(A)-binding proteins modulates the stability and translation of GNRH1 mRNA in mammalian puberty. Nucleic Acids Res. 2021 Apr 19;49(7):3796-3813
J:305000 Li C, et al., MKRN3 regulates the epigenetic switch of mammalian puberty via ubiquitination of MBD3. Natl Sci Rev. 2020 Mar;7(3):671-685
J:336754 Naule L, et al., MKRN3 inhibits puberty onset via interaction with IGF2BP1 and regulation of hypothalamic plasticity. JCI Insight. 2023 Apr 24;8(8)