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Sequence Detail
Q60760 Q91WC5 Q8BSH4 Q7TSA4 Q8BSS5 O35352 Q3TQ71 (UniProt | EBI) Last sequence update: 2005-01-04
Last annotation update: 2020-02-26
from provider
RecName: Full=Growth factor receptor-bound protein 10;AltName: Full=GRB10 adapter protein;AltName: Full=Maternally expressed gene 1 protein;
Polypeptide 621 aa
For this sequence
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Orthologs Phenotypic
Gene Grb10 growth factor receptor bound protein 10 38 89 9 45
Sequence references in MGI J:24927 Ooi J, et al., The cloning of Grb10 reveals a new family of SH2 domain proteins. Oncogene. 1995 Apr 20;10(8):1621-30
J:45655 Miyoshi N, et al., Identification of the Meg1/Grb10 imprinted gene on mouse proximal chromosome 11, a candidate for the Silver-Russell syndrome gene. Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):1102-7
J:51720 Laviola L, et al., The adapter protein Grb10 associates preferentially with the insulin receptor as compared with the IGF-I receptor in mouse fibroblasts. J Clin Invest. 1997 Mar 1;99(5):830-7
J:84425 Charalambous M, et al., Disruption of the imprinted Grb10 gene leads to disproportionate overgrowth by an Igf2-independent mechanism. Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8292-7
J:85099 Giovannone B, et al., Two novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling. J Biol Chem. 2003 Aug 22;278(34):31564-73
J:98784 Urschel S, et al., Phosphorylation of grb10 regulates its interaction with 14-3-3. J Biol Chem. 2005 Apr 29;280(17):16987-93
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:149197 Mori K, et al., Distinct Grb10 domain requirements for effects on glucose uptake and insulin signaling. Mol Cell Endocrinol. 2005 Jan 31;230(1-2):39-50
J:163129 Tezuka N, et al., GRB10 binds to LRP6, the Wnt co-receptor and inhibits canonical Wnt signaling pathway. Biochem Biophys Res Commun. 2007 May 11;356(3):648-54

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory