Sequence Detail

ID/Version

Q60680 Q9D2X3 Q80VU2 (UniProt | EBI)

Last sequence update: 1996-11-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Inhibitor of nuclear factor kappa-B kinase subunit alpha; Short=I-kappa-B kinase alpha; Short=IKK-A; Short=IKK-alpha; Short=IkBKA; Short=IkappaB kinase; EC=2.7.11.10 {ECO:0000250|UniProtKB:O151

Provider

SWISS-PROT

Sequence

Polypeptide 745 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Chuk	conserved helix-loop-helix ubiquitous kinase	105	107	3	35

Sequence references in MGI

J:26193 Mock BA, et al., CHUK, a conserved helix-loop-helix ubiquitous kinase, maps to human chromosome 10 and mouse chromosome 19. Genomics. 1995 May 20;27(2):348-51
J:35726 Connelly MA, et al., CHUK, a new member of the helix-loop-helix and leucine zipper families of interacting proteins, contains a serine-threonine kinase catalytic domain. Cell Mol Biol Res. 1995;41(6):537-49
J:54315 Takeda K, et al., Limb and skin abnormalities in mice lacking IKKalpha [see comments]. Science. 1999 Apr 9;284(5412):313-6
J:54768 Nakano H, et al., Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1. Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3537-42
J:60875 Jobin C, et al., The IkappaB/NF-kappaB system: a key determinant of mucosal inflammation and protection. Am J Physiol Cell Physiol. 2000 Mar;278(3):C451-62
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:131457 McKenzie FR, et al., Functional isoforms of IkappaB kinase alpha (IKKalpha) lacking leucine zipper and helix-loop-helix domains reveal that IKKalpha and IKKbeta have different activation requirements. Mol Cell Biol. 2000 Apr;20(8):2635-49
J:138472 Kizaki T, et al., Beta2-adrenergic receptor regulates Toll-like receptor-4-induced nuclear factor-kappaB activation through beta-arrestin 2. Immunology. 2008 Jul;124(3):348-56
J:163158 Teo H, et al., Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression. Nat Cell Biol. 2010 Aug;12(8):758-67
J:230351 Yamamoto Y, et al., Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression. Nature. 2003 Jun 5;423(6940):655-9
J:275558 Dondelinger Y, et al., Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation. Nat Commun. 2019 Apr 15;10(1):1729
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89