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Sequence Detail
Q60674 Q60646 (UniProt | EBI) Last sequence update: 1996-11-01
Last annotation update: 2019-10-16
from provider
RecName: Full=Nuclear receptor subfamily 1 group D member 2;AltName: Full=Orphan nuclear receptor RVR;AltName: Full=Rev-erb-beta;
Polypeptide 576 aa
For this sequence
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Orthologs Phenotypic
Gene Nr1d2 nuclear receptor subfamily 1, group D, member 2 50 11 8 10
Sequence references in MGI J:20436 Retnakaran R, et al., Identification of RVR, a novel orphan nuclear receptor that acts as a negative transcriptional regulator. Mol Endocrinol. 1994 Sep;8(9):1234-44
J:23754 Forman BM, et al., Cross-talk among ROR alpha 1 and the Rev-erb family of orphan nuclear receptors. Mol Endocrinol. 1994 Sep;8(9):1253-61
J:183623 Bugge A, et al., Rev-erbalpha and Rev-erbbeta coordinately protect the circadian clock and normal metabolic function. Genes Dev. 2012 Apr 1;26(7):657-67
J:203378 Yang F, et al., Real-time analysis of the circadian oscillation of the Rev-Erb beta promoter. J Atheroscler Thromb. 2013;20(3):267-76
J:203405 Ramakrishnan SN, et al., Rev-erb beta regulates the Srebp-1c promoter and mRNA expression in skeletal muscle cells. Biochem Biophys Res Commun. 2009 Oct 30;388(4):654-9
J:203407 Ramakrishnan SN, et al., Rev-erbbeta regulates the expression of genes involved in lipid absorption in skeletal muscle cells: evidence for cross-talk between orphan nuclear receptors and myokines. J Biol Chem. 2005 Mar 11;280(10):8651-9
J:264705 Pariollaud M, et al., Circadian clock component REV-ERBalpha controls homeostatic regulation of pulmonary inflammation. J Clin Invest. 2018 Jun 1;128(6):2281-2296
J:265505 Amador A, et al., Distinct roles for REV-ERBalpha and REV-ERBbeta in oxidative capacity and mitochondrial biogenesis in skeletal muscle. PLoS One. 2018;13(5):e0196787
J:273537 Ohba Y, et al., Phosphorylation of N-terminal regions of REV-ERBs regulates their intracellular localization. Genes Cells. 2018 Apr;23(4):285-293
J:273898 Amador A, et al., REV-ERBbeta is required to maintain normal wakefulness and the wake-inducing effect of dual REV-ERB agonist SR9009. Biochem Pharmacol. 2018 Apr;150:1-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory