Sequence Detail

ID/Version

Q60674 Q60646 (UniProt | EBI)

Last sequence update: 1996-11-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Nuclear receptor subfamily 1 group D member 2 {ECO:0000305};AltName: Full=Orphan nuclear receptor RVR;AltName: Full=Rev-erb-beta;

Provider

SWISS-PROT

Sequence

Polypeptide 576 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nr1d2	nuclear receptor subfamily 1, group D, member 2	58	109	4	17

Sequence references in MGI

J:20436 Retnakaran R, et al., Identification of RVR, a novel orphan nuclear receptor that acts as a negative transcriptional regulator. Mol Endocrinol. 1994 Sep;8(9):1234-44
J:23754 Forman BM, et al., Cross-talk among ROR alpha 1 and the Rev-erb family of orphan nuclear receptors. Mol Endocrinol. 1994 Sep;8(9):1253-61
J:183623 Bugge A, et al., Rev-erbalpha and Rev-erbbeta coordinately protect the circadian clock and normal metabolic function. Genes Dev. 2012 Apr 1;26(7):657-67
J:203378 Yang F, et al., Real-time analysis of the circadian oscillation of the Rev-Erb beta promoter. J Atheroscler Thromb. 2013;20(3):267-76
J:203405 Ramakrishnan SN, et al., Rev-erb beta regulates the Srebp-1c promoter and mRNA expression in skeletal muscle cells. Biochem Biophys Res Commun. 2009 Oct 30;388(4):654-9
J:203407 Ramakrishnan SN, et al., Rev-erbbeta regulates the expression of genes involved in lipid absorption in skeletal muscle cells: evidence for cross-talk between orphan nuclear receptors and myokines. J Biol Chem. 2005 Mar 11;280(10):8651-9
J:264705 Pariollaud M, et al., Circadian clock component REV-ERBalpha controls homeostatic regulation of pulmonary inflammation. J Clin Invest. 2018 Jun 1;128(6):2281-2296
J:265505 Amador A, et al., Distinct roles for REV-ERBalpha and REV-ERBbeta in oxidative capacity and mitochondrial biogenesis in skeletal muscle. PLoS One. 2018;13(5):e0196787
J:273537 Ohba Y, et al., Phosphorylation of N-terminal regions of REV-ERBs regulates their intracellular localization. Genes Cells. 2018 Apr;23(4):285-293
J:273898 Amador A, et al., REV-ERBbeta is required to maintain normal wakefulness and the wake-inducing effect of dual REV-ERB agonist SR9009. Biochem Pharmacol. 2018 Apr;150:1-8
J:319841 Liu AC, et al., Redundant function of REV-ERBalpha and beta and non-essential role for Bmal1 cycling in transcriptional regulation of intracellular circadian rhythms. PLoS Genet. 2008 Feb 29;4(2):e1000023
J:356901 Lam MT, et al., Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription. Nature. 2013 Jun 27;498(7455):511-5