Sequence Detail

ID/Version

Q60673 Q62129 E9Q746 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Receptor-type tyrosine-protein phosphatase-like N; Short=R-PTP-N;AltName: Full=PTP IA-2 {ECO:0000305};Contains: RecName: Full=ICA512-N-terminal fragment; Short=ICA512-NTF;Contains: RecName: Full=ICA512-transmembrane fragm

Provider

SWISS-PROT

Sequence

Polypeptide 979 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ptprn	protein tyrosine phosphatase receptor type N	52	102	4	12

Sequence references in MGI

J:21080 Lu J, et al., Isolation, sequence and expression of a novel mouse brain cDNA, mIA-2, and its relatedness to members of the protein tyrosine phosphatase family. Biochem Biophys Res Commun. 1994 Oct 28;204(2):930-6
J:30016 Magistrelli G, et al., Expression of PTP35, the murine homologue of the protein tyrosine phosphatase-related sequence IA-2, is regulated during cell growth and stimulated by mitogens in 3T3 fibroblasts. Biochem Biophys Res Commun. 1995 Dec 5;217(1):154-61
J:108765 Saeki K, et al., Targeted disruption of the protein tyrosine phosphatase-like molecule IA-2 results in alterations in glucose tolerance tests and insulin secretion. Diabetes. 2002 Jun;51(6):1842-50
J:129445 Kubosaki A, et al., Disruption of the transmembrane dense core vesicle proteins IA-2 and IA-2beta causes female infertility. Endocrinology. 2006 Feb;147(2):811-5
J:131027 Mziaut H, et al., ICA512 signaling enhances pancreatic beta-cell proliferation by regulating cyclins D through STATs. Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):674-9
J:144745 Kim SM, et al., Dense-core vesicle proteins IA-2 and IA-2{beta} affect renin synthesis and secretion through the {beta}-adrenergic pathway. Am J Physiol Renal Physiol. 2009 Feb;296(2):F382-9
J:148933 Nishimura T, et al., Disturbances in the secretion of neurotransmitters in IA-2/IA-2beta null mice: changes in behavior, learning and lifespan. Neuroscience. 2009 Mar 17;159(2):427-37
J:174841 Cai T, et al., Deletion of Ia-2 and/or Ia-2beta in mice decreases insulin secretion by reducing the number of dense core vesicles. Diabetologia. 2011 Sep;54(9):2347-57
J:200322 Gross S, et al., Multimerization of the protein-tyrosine phosphatase (PTP)-like insulin-dependent diabetes mellitus autoantigens IA-2 and IA-2beta with receptor PTPs (RPTPs). Inhibition of RPTPalpha enzymatic activity. J Biol Chem. 2002 Dec 13;277(50):48139-45
J:215442 Magistrelli G, et al., Substitution of two variant residues in the protein tyrosine phosphatase-like PTP35/IA-2 sequence reconstitutes catalytic activity. Biochem Biophys Res Commun. 1996 Oct 14;227(2):581-8
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89