Sequence Detail

ID/Version

Q60670 Q3UR46 (UniProt | EBI)

Last sequence update: 2011-10-19
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Serine/threonine-protein kinase SIK1; EC=2.7.11.1 {ECO:0000269|PubMed:15177563, ECO:0000269|PubMed:16148943, ECO:0000269|PubMed:17468767, ECO:0000269|PubMed:19244231};AltName: Full=HRT-20;AltName: Full=Myocardial SNF1-like kinase;Alt

Provider

SWISS-PROT

Sequence

Polypeptide 779 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Sik1	salt inducible kinase 1	77	109	3	23

Sequence references in MGI

J:22208 Ruiz JC, et al., Identification of novel protein kinases expressed in the myocardium of the developing mouse heart. Mech Dev. 1994 Dec;48(3):153-64
J:79888 Takemori H, et al., ACTH-induced nucleocytoplasmic translocation of salt-inducible kinase. Implication in the protein kinase A-activated gene transcription in mouse adrenocortical tumor cells. J Biol Chem. 2002 Nov 1;277(44):42334-43
J:90713 Stephenson A, et al., snf1lk encodes a protein kinase that may function in cell cycle regulation. Genomics. 2004 Jun;83(6):1105-15
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:102116 Koo SH, et al., The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. Nature. 2005 Oct 20;437(7062):1109-11
J:121527 Katoh Y, et al., Silencing the constitutive active transcription factor CREB by the LKB1-SIK signaling cascade. FEBS J. 2006 Jun;273(12):2730-48
J:121892 Berdeaux R, et al., SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes. Nat Med. 2007 May;13(5):597-603
J:158005 Romito A, et al., Lack of sik1 in mouse embryonic stem cells impairs cardiomyogenesis by down-regulating the cyclin-dependent kinase inhibitor p57kip2. PLoS One. 2010;5(2):e9029
J:168286 Cheng H, et al., SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis. Sci Signal. 2009;2(80):ra35
J:177249 Yoon YS, et al., Salt-inducible kinase regulates hepatic lipogenesis by controlling SREBP-1c phosphorylation. J Biol Chem. 2009 Apr 17;284(16):10446-52
J:204540 Jagannath A, et al., The CRTC1-SIK1 pathway regulates entrainment of the circadian clock. Cell. 2013 Aug 29;154(5):1100-11