Sequence Detail

ID/Version

Q60662 B1AXM7 Q60630 Q8R2G7 (UniProt | EBI)

Last sequence update: 1996-11-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=A-kinase anchor protein 4 {ECO:0000303|PubMed:12606363}; Short=AKAP-4 {ECO:0000303|PubMed:12606363};AltName: Full=A-kinase anchor protein 82 kDa {ECO:0000303|PubMed:8088444}; Short=AKAP 82 {ECO:0000303|PubMed:8088444};

Provider

SWISS-PROT

Sequence

Polypeptide 849 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Akap4	A kinase anchor protein 4	47	96	2	5

Sequence references in MGI

J:20326 Carrera A, et al., The major fibrous sheath polypeptide of mouse sperm: structural and functional similarities to the A-kinase anchoring proteins. Dev Biol. 1994 Sep;165(1):272-84
J:22348 Fulcher KD, et al., Characterization of Fsc1 cDNA for a mouse sperm fibrous sheath component. Biol Reprod. 1995 Jan;52(1):41-9
J:52123 Miki K, et al., Identification of tethering domains for protein kinase A type Ialpha regulatory subunits on sperm fibrous sheath protein FSC1. J Biol Chem. 1998 Dec 18;273(51):34384-90
J:83525 Brown PR, et al., A-kinase anchoring protein 4 binding proteins in the fibrous sheath of the sperm flagellum. Biol Reprod. 2003 Jun;68(6):2241-8
J:86899 Miki K, et al., Targeted disruption of the Akap4 gene causes defects in sperm flagellum and motility. Dev Biol. 2002 Aug 15;248(2):331-42
J:202075 Nakamura N, et al., Disruption of a spermatogenic cell-specific mouse enolase 4 (eno4) gene causes sperm structural defects and male infertility. Biol Reprod. 2013 Apr;88(4):90
J:280424 Fang X, et al., Proteomics and single-cell RNA analysis of Akap4-knockout mice model confirm indispensable role of Akap4 in spermatogenesis. Dev Biol. 2019 Oct 15;454(2):118-127
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:326368 Kaneda Y, et al., IRGC1, a testis-enriched immunity related GTPase, is important for fibrous sheath integrity and sperm motility in mice. Dev Biol. 2022 Aug;488:104-113
J:352416 Wei H, et al., A pathogenic AKAP4 variant, p.R429H, causes male in/subfertility in humans and mice. Clin Transl Med. 2023 Dec;13(12):e1463
J:352418 Yu W, et al., STK33 Phosphorylates Fibrous Sheath Protein AKAP3/4 to Regulate Sperm Flagella Assembly in Spermiogenesis. Mol Cell Proteomics. 2023 Jun;22(6):100564