Sequence Detail

ID/Version

Q60644 (UniProt | EBI)

Last sequence update: 1996-11-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Oxysterols receptor LXR-beta;AltName: Full=Liver X receptor beta;AltName: Full=Nuclear receptor subfamily 1 group H member 2;AltName: Full=Retinoid X receptor-interacting protein No.15;AltName: Full=Ubiquitously-expressed nuclear receptor;

Provider

SWISS-PROT

Sequence

Polypeptide 446 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nr1h2	nuclear receptor subfamily 1, group H, member 2	79	107	2	12

Sequence references in MGI

J:23077 Seol W, et al., Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors. Mol Endocrinol. 1995 Jan;9(1):72-85
J:60322 Alberti S, et al., Structural characterisation of the mouse nuclear oxysterol receptor genes LXRalpha and LXRbeta. Gene. 2000 Feb 8;243(1-2):93-103
J:150132 Zelcer N, et al., LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor. Science. 2009 Jul 3;325(5936):100-4
J:206173 Rong X, et al., LXRs regulate ER stress and inflammation through dynamic modulation of membrane phospholipid composition. Cell Metab. 2013 Nov 5;18(5):685-97
J:206917 Wada T, et al., Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3). Mol Pharmacol. 2008 Mar;73(3):891-9
J:220827 Rong X, et al., Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion. Elife. 2015;4
J:252691 Rong X, et al., ER phospholipid composition modulates lipogenesis during feeding and in obesity. J Clin Invest. 2017 Oct 02;127(10):3640-3651