Sequence Detail

ID/Version

Q60641 Q60642 Q60643 E9QJW2 D3YTT2 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Bile acid receptor;AltName: Full=Farnesoid X-activated receptor;AltName: Full=Farnesol receptor HRR-1;AltName: Full=Nuclear receptor subfamily 1 group H member 4;AltName: Full=Retinoid X receptor-interacting protein 14; Short=RXR-int

Provider

SWISS-PROT

Sequence

Polypeptide 488 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nr1h4	nuclear receptor subfamily 1, group H, member 4	158	109	3	22

Sequence references in MGI

J:23077 Seol W, et al., Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors. Mol Endocrinol. 1995 Jan;9(1):72-85
J:64792 Sinal CJ, et al., Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell. 2000 Sep 15;102(6):731-44
J:77878 Cui J, et al., The amino Acid residues asparagine 354 and isoleucine 372 of human farnesoid x receptor confer the receptor with high sensitivity to chenodeoxycholate. J Biol Chem. 2002 Jul 19;277(29):25963-9
J:81724 Lambert G, et al., The Farnesoid X-receptor Is an Essential Regulator of Cholesterol Homeostasis. J Biol Chem. 2003 Jan 24;278(4):2563-70
J:87780 Zhang Y, et al., Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR. Genes Dev. 2004 Jan 15;18(2):157-69
J:105654 Zhang Y, et al., Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice. Proc Natl Acad Sci U S A. 2006 Jan 24;103(4):1006-11
J:107133 Inagaki T, et al., Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor. Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3920-5
J:107809 Ma K, et al., Farnesoid X receptor is essential for normal glucose homeostasis. J Clin Invest. 2006 Apr;116(4):1102-9
J:110560 Cariou B, et al., The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice. J Biol Chem. 2006 Apr 21;281(16):11039-49
J:120199 Watanabe M, et al., Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. J Clin Invest. 2004 May;113(10):1408-18
J:129677 Inagaki T, et al., Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab. 2005 Oct;2(4):217-25
J:142094 Modica S, et al., Nuclear bile acid receptor FXR protects against intestinal tumorigenesis. Cancer Res. 2008 Dec 1;68(23):9589-94
J:143606 Fang S, et al., The p300 acetylase is critical for ligand-activated farnesoid X receptor (FXR) induction of SHP. J Biol Chem. 2008 Dec 12;283(50):35086-95
J:154989 Miao J, et al., Functional specificities of Brm and Brg-1 Swi/Snf ATPases in the feedback regulation of hepatic bile acid biosynthesis. Mol Cell Biol. 2009 Dec;29(23):6170-81
J:155433 Kemper JK, et al., FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states. Cell Metab. 2009 Nov;10(5):392-404
J:157174 Vavassori P, et al., The bile acid receptor FXR is a modulator of intestinal innate immunity. J Immunol. 2009 Nov 15;183(10):6251-61
J:161322 Popescu IR, et al., The nuclear receptor FXR is expressed in pancreatic beta-cells and protects human islets from lipotoxicity. FEBS Lett. 2010 Jul 2;584(13):2845-51
J:173426 Chong HK, et al., Genome-wide interrogation of hepatic FXR reveals an asymmetric IR-1 motif and synergy with LRH-1. Nucleic Acids Res. 2010 Oct;38(18):6007-17
J:178263 Chennamsetty I, et al., Farnesoid X receptor represses hepatic human APOA gene expression. J Clin Invest. 2011 Sep 1;121(9):3724-34
J:195920 Renga B, et al., The bile acid sensor FXR is required for immune-regulatory activities of TLR-9 in intestinal inflammation. PLoS One. 2013;8(1):e54472
J:219776 de Aguiar Vallim TQ, et al., MAFG is a transcriptional repressor of bile acid synthesis and metabolism. Cell Metab. 2015 Feb 3;21(2):298-310
J:228417 Claudel T, et al., Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression. Gastroenterology. 2003 Aug;125(2):544-55
J:228561 Wang YD, et al., Farnesoid X receptor antagonizes nuclear factor kappaB in hepatic inflammatory response. Hepatology. 2008 Nov;48(5):1632-43
J:228635 Gadaleta RM, et al., Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease. Gut. 2011 Apr;60(4):463-72
J:234054 Fu T, et al., FXR Primes the Liver for Intestinal FGF15 Signaling by Transient Induction of beta-Klotho. Mol Endocrinol. 2016 Jan;30(1):92-103
J:319839 Modica S, et al., Selective activation of nuclear bile acid receptor FXR in the intestine protects mice against cholestasis. Gastroenterology. 2012 Feb;142(2):355-65.e1-4