Sequence Detail

ID/Version

Q60610 (UniProt | EBI)

Last sequence update: 1996-11-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Rho guanine nucleotide exchange factor TIAM1 {ECO:0000305};AltName: Full=T-lymphoma invasion and metastasis-inducing protein 1 {ECO:0000305|PubMed:7999144}; Short=TIAM-1 {ECO:0000303|PubMed:7999144};

Provider

SWISS-PROT

Sequence

Polypeptide 1591 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tiam1	T cell lymphoma invasion and metastasis 1	85	108	4	31

Sequence references in MGI

J:18555 Habets GG, et al., Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins. Cell. 1994 May 20;77(4):537-49
J:156410 Terawaki S, et al., The PHCCEx domain of Tiam1/2 is a novel protein- and membrane-binding module. EMBO J. 2010 Jan 6;29(1):236-50
J:180470 Miyamoto Y, et al., TrkB binds and tyrosine-phosphorylates Tiam1, leading to activation of Rac1 and induction of changes in cellular morphology. Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10444-9
J:263376 Trinidad JC, et al., Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Mol Cell Proteomics. 2006 May;5(5):914-22
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89