Sequence Detail

ID/Version

Q60520 Q62139 Q7TSZ2 Q62140 Q570Z7 Q60820 Q7TPU8 (UniProt | EBI)

Last sequence update: 2010-10-05
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Paired amphipathic helix protein Sin3a;AltName: Full=Histone deacetylase complex subunit Sin3a;AltName: Full=Transcriptional corepressor Sin3a;

Provider

SWISS-PROT

Sequence

Polypeptide 1274 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Sin3a	transcriptional regulator, SIN3A (yeast)	133	120	4	46

Sequence references in MGI

J:28926 Halleck MS, et al., A widely distributed putative mammalian transcriptional regulator containing multiple paired amphipathic helices, with similarity to yeast SIN3. Genomics. 1995 Mar 20;26(2):403-6
J:29949 Hurlin PJ, et al., Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation. EMBO J. 1995 Nov 15;14(22):5646-59
J:31975 Rao G, et al., Mouse Sin3A interacts with and can functionally substitute for the amino-terminal repression of the Myc antagonist Mxi1. Oncogene. 1996 Mar 7;12(5):1165-72
J:32479 Ayer DE, et al., Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3. Cell. 1995 Mar 10;80(5):767-76
J:61357 Grimes JA, et al., The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex. J Biol Chem. 2000 Mar 31;275(13):9461-7
J:66985 Laherty CD, et al., SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors. Mol Cell. 1998 Jul;2(1):33-42
J:82069 Yang L, et al., An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B. Biochem J. 2003 Feb 1;369(Pt 3):651-7
J:84768 Alland L, et al., Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex. Mol Cell Biol. 2002 Apr;22(8):2743-50
J:104339 Li X, et al., Tissue-specific regulation of retinal and pituitary precursor cell proliferation. Science. 2002 Aug 16;297(5584):1180-3
J:144189 Jacobs FM, et al., Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression. Development. 2009 Feb;136(4):531-40
J:150926 Zhou Y, et al., The chromatin remodeling complex NoRC targets HDAC1 to the ribosomal gene promoter and represses RNA polymerase I transcription. EMBO J. 2002 Sep 2;21(17):4632-40
J:159082 Yochum GS, et al., Pf1, a novel PHD zinc finger protein that links the TLE corepressor to the mSin3A-histone deacetylase complex. Mol Cell Biol. 2001 Jul;21(13):4110-8
J:161034 Ostendorff HP, et al., Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors. Nature. 2002 Mar 7;416(6876):99-103
J:169899 Brown MA, et al., Identification and characterization of Smyd2: a split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex. Mol Cancer. 2006;5:26
J:172063 Williams K, et al., TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity. Nature. 2011 May 19;473(7347):343-8
J:173532 Duong HA, et al., A molecular mechanism for circadian clock negative feedback. Science. 2011 Jun 17;332(6036):1436-9
J:196237 Shi X, et al., Sin3 interacts with Foxk1 and regulates myogenic progenitors. Mol Cell Biochem. 2012 Jul;366(1-2):251-8
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:217746 Bowman CJ, et al., Foxk proteins repress the initiation of starvation-induced atrophy and autophagy programs. Nat Cell Biol. 2014 Dec;16(12):1202-14
J:227377 Lu P, et al., The developmental regulator protein Gon4l associates with protein YY1, co-repressor Sin3a, and histone deacetylase 1 and mediates transcriptional repression. J Biol Chem. 2011 May 20;286(20):18311-9
J:243422 Streubel G, et al., Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells required for self-renewal. EMBO J. 2017 Aug 01;36(15):2216-2232
J:281257 Witteveen JS, et al., Haploinsufficiency of MeCP2-interacting transcriptional co-repressor SIN3A causes mild intellectual disability by affecting the development of cortical integrity. Nat Genet. 2016 Aug;48(8):877-87
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89