Sequence Detail

ID/Version

Q5SWZ9 Q3UTA3 Q8BVM0 B7ZN71 (UniProt | EBI)

Last sequence update: 2004-12-21
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Mitochondrial cardiolipin hydrolase; EC=3.1.4.- {ECO:0000250|UniProtKB:Q8N2A8};AltName: Full=Choline phosphatase 6;AltName: Full=Mitochondrial phospholipase {ECO:0000250|UniProtKB:Q8N2A8}; Short=MitoPLD {ECO:0000250|UniProtKB

Provider

SWISS-PROT

Sequence

Polypeptide 221 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pld6	phospholipase D family member 6	46	96	3	7

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:169933 Huang H, et al., piRNA-Associated Germline Nuage Formation and Spermatogenesis Require MitoPLD Profusogenic Mitochondrial-Surface Lipid Signaling. Dev Cell. 2011 Mar 15;20(3):376-87
J:169934 Watanabe T, et al., MITOPLD Is a Mitochondrial Protein Essential for Nuage Formation and piRNA Biogenesis in the Mouse Germline. Dev Cell. 2011 Mar 15;20(3):364-75
J:189220 Ipsaro JJ, et al., The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis. Nature. 2012 Nov 8;491(7423):279-83
J:221349 Vourekas A, et al., The RNA helicase MOV10L1 binds piRNA precursors to initiate piRNA processing. Genes Dev. 2015 Mar 15;29(6):617-29
J:227409 von Eyss B, et al., A MYC-Driven Change in Mitochondrial Dynamics Limits YAP/TAZ Function in Mammary Epithelial Cells and Breast Cancer. Cancer Cell. 2015 Dec 14;28(6):743-57
J:231271 Nishimasu H, et al., Structure and function of Zucchini endoribonuclease in piRNA biogenesis. Nature. 2012 Nov 8;491(7423):284-7
J:278636 Chen Y, et al., Glycerol kinase-like proteins cooperate with Pld6 in regulating sperm mitochondrial sheath formation and male fertility. Cell Discov. 2017;3:17030
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89