Sequence Detail

ID/Version

Q5MPP0 Q8BTH1 Q5RL53 Q8R0M0 Q8R0V1 Q2M2M0 (UniProt | EBI)

Last sequence update: 2005-02-01
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Fatty acid 2-hydroxylase {ECO:0000303|PubMed:15658937, ECO:0000303|PubMed:18815260, ECO:0000303|PubMed:21628453, ECO:0000303|PubMed:22517924}; EC=1.14.18.- {ECO:0000269|PubMed:22517924};AltName: Full=Fatty acid alpha-hydroxylase;

Provider

SWISS-PROT

Sequence

Polypeptide 372 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Fa2h	fatty acid 2-hydroxylase	34	105	3	14

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:117271 Alderson NL, et al., FA2H-dependent fatty acid 2-hydroxylation in postnatal mouse brain. J Lipid Res. 2006 Dec;47(12):2772-80
J:117530 Eckhardt M, et al., A mammalian fatty acid hydroxylase responsible for the formation of alpha-hydroxylated galactosylceramide in myelin. Biochem J. 2005 May 15;388(Pt 1):245-54
J:143373 Zoller I, et al., Absence of 2-hydroxylated sphingolipids is compatible with normal neural development but causes late-onset axon and myelin sheath degeneration. J Neurosci. 2008 Sep 24;28(39):9741-54
J:175386 Maier H, et al., Normal fur development and sebum production depends on fatty acid 2-hydroxylase expression in sebaceous glands. J Biol Chem. 2011 Jul 22;286(29):25922-34
J:266470 Guo L, et al., Stereospecificity of fatty acid 2-hydroxylase and differential functions of 2-hydroxy fatty acid enantiomers. J Lipid Res. 2012 Jul;53(7):1327-35