Sequence Detail

ID/Version

Q5FWH3 A2ADI2 (UniProt | EBI)

Last sequence update: 2005-03-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Grainyhead-like protein 3 homolog {ECO:0000312|MGI:MGI:2655333};AltName: Full=Transcription factor CP2-like 4;

Provider

SWISS-PROT

Sequence

Polypeptide 603 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Grhl3	grainyhead like transcription factor 3	53	132	3	77

Sequence references in MGI

J:86772 Ting SB, et al., Inositol- and folate-resistant neural tube defects in mice lacking the epithelial-specific factor Grhl-3. Nat Med. 2003 Dec;9(12):1513-9
J:114626 Yu Z, et al., The Grainyhead-like epithelial transactivator Get-1/Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4. Dev Biol. 2006 Nov 1;299(1):122-36
J:164805 Rifat Y, et al., Regional neural tube closure defined by the Grainy head-like transcription factors. Dev Biol. 2010 Sep 15;345(2):237-45
J:168020 Boglev Y, et al., The unique and cooperative roles of the Grainy head-like transcription factors in epidermal development reflect unexpected target gene specificity. Dev Biol. 2011 Jan 15;349(2):512-22
J:218401 Gordon WM, et al., A GRHL3-regulated repair pathway suppresses immune-mediated epidermal hyperplasia. J Clin Invest. 2014 Dec;124(12):5205-18
J:226218 Peyrard-Janvid M, et al., Dominant mutations in GRHL3 cause Van der Woude Syndrome and disrupt oral periderm development. Am J Hum Genet. 2014 Jan 2;94(1):23-32