Sequence Detail

ID/Version

Q5EG47 (UniProt | EBI)

Last sequence update: 2009-07-28
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=5'-AMP-activated protein kinase catalytic subunit alpha-1; Short=AMPK subunit alpha-1; EC=2.7.11.1 {ECO:0000250|UniProtKB:P54645};AltName: Full=Acetyl-CoA carboxylase kinase; Short=ACACA kinase;AltName: Full=Hydroxyme

Provider

SWISS-PROT

Sequence

Polypeptide 559 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Prkaa1	protein kinase, AMP-activated, alpha 1 catalytic subunit	196	126	3	35

Sequence references in MGI

J:102116 Koo SH, et al., The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. Nature. 2005 Oct 20;437(7062):1109-11
J:104202 Shaw RJ, et al., The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science. 2005 Dec 9;310(5754):1642-6
J:111856 Kramer HF, et al., Distinct signals regulate AS160 phosphorylation in response to insulin, AICAR, and contraction in mouse skeletal muscle. Diabetes. 2006 Jul;55(7):2067-76
J:111858 Treebak JT, et al., AMPK-mediated AS160 phosphorylation in skeletal muscle is dependent on AMPK catalytic and regulatory subunits. Diabetes. 2006 Jul;55(7):2051-8
J:129788 Hawley SA, et al., Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. Cell Metab. 2005 Jul;2(1):9-19
J:136666 Gwinn DM, et al., AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell. 2008 Apr 25;30(2):214-26
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:153754 Lamia KA, et al., AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation. Science. 2009 Oct 16;326(5951):437-40
J:160348 Zhao J, et al., AMP-activated protein kinase (AMPK) cross-talks with canonical Wnt signaling via phosphorylation of beta-catenin at Ser 552. Biochem Biophys Res Commun. 2010 Apr 23;395(1):146-51
J:163548 Bungard D, et al., Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation. Science. 2010 Sep 3;329(5996):1201-5
J:167980 Egan DF, et al., Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science. 2011 Jan 28;331(6016):456-61
J:172248 Li Y, et al., AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab. 2011 Apr 6;13(4):376-88
J:175186 Daval M, et al., Anti-lipolytic action of AMP-activated protein kinase in rodent adipocytes. J Biol Chem. 2005 Jul 1;280(26):25250-7
J:175316 Kim J, et al., AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol. 2011 Feb;13(2):132-41
J:257325 Peserico A, et al., A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels. Cell Mol Life Sci. 2013 Jun;70(11):2015-29
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:303713 Van Nostrand JL, et al., AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation. Genes Dev. 2020 Oct 1;34(19-20):1330-1344
J:319691 Liu R, et al., Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets. Mol Cell. 2021 Jul 1;81(13):2722-2735.e9
J:338255 Cheng L, et al., Hepatic mitochondrial NAD + transporter SLC25A47 activates AMPKalpha mediating lipid metabolism and tumorigenesis. Hepatology. 2023 Feb 22;