Sequence Detail

ID/Version

Q5DU56 A1L3P6 Q3TAB7 Q8BJF4 Q8BV65 (UniProt | EBI)

Last sequence update: 2007-07-24
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Protein NLRC3;

Provider

SWISS-PROT

Sequence

Polypeptide 1064 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nlrc3	NLR family, CARD domain containing 3	48	97	3	13

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:187586 Schneider M, et al., The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-kappaB. Nat Immunol. 2012 Aug 5;13(9):823-31
J:209896 Zhang L, et al., NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING. Immunity. 2014 Mar 20;40(3):329-41
J:240431 Karki R, et al., NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer. Nature. 2016 Dec 12;