Sequence Detail

ID/Version

Q5DU02 Q3U2W4 Q66JV8 Q5SU81 Q6PDX3 Q3TU34 Q8BJG3 (UniProt | EBI)

Last sequence update: 2005-09-13
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Ubiquitin carboxyl-terminal hydrolase 22; EC=3.4.19.12;AltName: Full=Deubiquitinating enzyme 22;AltName: Full=Ubiquitin thioesterase 22;AltName: Full=Ubiquitin-specific-processing protease 22;

Provider

SWISS-PROT

Sequence

Polypeptide 525 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Usp22	ubiquitin specific peptidase 22	54	105	3	19

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:105884 Lee HJ, et al., The expression patterns of deubiquitinating enzymes, USP22 and Usp22. Gene Expr Patterns. 2006 Mar;6(3):277-84
J:188021 Lin Z, et al., USP22 antagonizes p53 transcriptional activation by deubiquitinating Sirt1 to suppress cell apoptosis and is required for mouse embryonic development. Mol Cell. 2012 May 25;46(4):484-94
J:235307 Weber A, et al., The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis. EMBO Rep. 2016 May;17(5):724-38
J:289911 Zhang Y, et al., USP22 controls iNKT immunity through MED1 suppression of histone H2A monoubiquitination. J Exp Med. 2020 May 4;217(5)