Sequence Detail

ID/Version

Q5D1E7 Q922T4 Q3U8J3 Q8JZW9 Q3UE76 (UniProt | EBI)

Last sequence update: 2008-06-10
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=Endoribonuclease ZC3H12A {ECO:0000305}; EC=3.1.-.- {ECO:0000269|PubMed:19322177};AltName: Full=Monocyte chemotactic protein-induced protein 1 {ECO:0000303|PubMed:21115689}; Short=MCP-induced protein 1 {ECO:0000303|PubMed:1657

Provider

SWISS-PROT

Sequence

Polypeptide 596 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Zc3h12a	zinc finger CCCH type containing 12A	193	97	3	30

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:140125 Liang J, et al., Genome-wide survey and expression profiling of CCCH-zinc finger family reveals a functional module in macrophage activation. PLoS One. 2008;3(8):e2880
J:147868 Matsushita K, et al., Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay. Nature. 2009 Apr 30;458(7242):1185-90
J:174994 Niu J, et al., MCP-1-induced protein attenuates endotoxin-induced myocardial dysfunction by suppressing cardiac NF-small ka, CyrillicB activation via inhibition of Ismall ka, CyrillicB kinase activation. J Mol Cell Cardiol. 2011 Aug;51(2):177-86
J:176866 Liang J, et al., MCP-induced protein 1 deubiquitinates TRAF proteins and negatively regulates JNK and NF-kappaB signaling. J Exp Med. 2010 Dec 20;207(13):2959-73
J:178149 Qi D, et al., Monocyte Chemotactic Protein-induced Protein 1 (MCPIP1) Suppresses Stress Granule Formation and Determines Apoptosis under Stress. J Biol Chem. 2011 Dec 2;286(48):41692-700
J:179016 Iwasaki H, et al., The IkappaB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1. Nat Immunol. 2011 Dec;12(12):1167-75
J:196097 Liang J, et al., A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages. J Biol Chem. 2008 Mar 7;283(10):6337-46
J:196233 Younce C, et al., MCP-1 induced protein promotes adipogenesis via oxidative stress, endoplasmic reticulum stress and autophagy. Cell Physiol Biochem. 2012;30(2):307-20
J:198415 Uehata T, et al., Malt1-induced cleavage of regnase-1 in CD4(+) helper T cells regulates immune activation. Cell. 2013 May 23;153(5):1036-49
J:228359 Mino T, et al., Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms. Cell. 2015 May 21;161(5):1058-73
J:228409 Li M, et al., MCPIP1 down-regulates IL-2 expression through an ARE-independent pathway. PLoS One. 2012;7(11):e49841
J:228414 Younce CW, et al., MCP-1 (monocyte chemotactic protein-1)-induced protein, a recently identified zinc finger protein, induces adipogenesis in 3T3-L1 pre-adipocytes without peroxisome proliferator-activated receptor gamma. J Biol Chem. 2009 Oct 2;284(40):27620-8
J:228416 Zhou L, et al., Monocyte chemoattractant protein-1 induces a novel transcription factor that causes cardiac myocyte apoptosis and ventricular dysfunction. Circ Res. 2006 May 12;98(9):1177-85
J:228445 Huang S, et al., Monocyte Chemotactic Protein-induced Protein 1 and 4 Form a Complex but Act Independently in Regulation of Interleukin-6 mRNA Degradation. J Biol Chem. 2015 Aug 21;290(34):20782-92
J:233655 Garg AV, et al., MCPIP1 Endoribonuclease Activity Negatively Regulates Interleukin-17-Mediated Signaling and Inflammation. Immunity. 2015 Sep 15;43(3):475-87
J:244458 Kapoor N, et al., Transcription factors STAT6 and KLF4 implement macrophage polarization via the dual catalytic powers of MCPIP. J Immunol. 2015 Jun 15;194(12):6011-23
J:259145 Jeltsch KM, et al., Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T(H)17 differentiation. Nat Immunol. 2014 Nov;15(11):1079-89
J:261340 Hanieh H, et al., Arid5a stabilizes OX40 mRNA in murine CD4(+) T cells by recognizing a stem-loop structure in its 3'UTR. Eur J Immunol. 2018 Apr;48(4):593-604