Sequence Detail

ID/Version

Q58FA4 Q497V7 Q8BQJ5 Q8C3Y5 Q5PRE4 Q3U4W2 (UniProt | EBI)

Last sequence update: 2005-04-26
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Transcription factor E2F8; Short=E2F-8;

Provider

SWISS-PROT

Sequence

Polypeptide 860 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	E2f8	E2F transcription factor 8	49	98	3	9

Sequence references in MGI

J:99083 Maiti B, et al., Cloning and characterization of mouse E2F8, a novel mammalian E2F family member capable of blocking cellular proliferation. J Biol Chem. 2005 May 6;280(18):18211-20
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:131292 Li J, et al., Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development. Dev Cell. 2008 Jan;14(1):62-75
J:183999 Ouseph MM, et al., Atypical E2F repressors and activators coordinate placental development. Dev Cell. 2012 Apr 17;22(4):849-62
J:189923 Weijts BG, et al., E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1. EMBO J. 2012 Oct 3;31(19):3871-84
J:190713 Chen HZ, et al., Canonical and atypical E2Fs regulate the mammalian endocycle. Nat Cell Biol. 2012 Nov;14(11):1192-202
J:190714 Pandit SK, et al., E2F8 is essential for polyploidization in mammalian cells. Nat Cell Biol. 2012 Nov;14(11):1181-91
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89