Sequence Detail

ID/Version

Q505F1 Q60927 Q62152 P97763 Q4U1Z4 Q3UIJ7 Q0VGP8 Q8VIJ3 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Nuclear receptor subfamily 2 group C member 1;AltName: Full=Orphan nuclear receptor TR2;AltName: Full=Testicular receptor 2; Short=mTR2;

Provider

SWISS-PROT

Sequence

Polypeptide 590 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nr2c1	nuclear receptor subfamily 2, group C, member 1	36	116	3	37

Sequence references in MGI

J:29690 Lee CH, et al., Genomic structure, promoter identification, and chromosomal mapping of a mouse nuclear orphan receptor expressed in embryos and adult testes. Genomics. 1995 Nov 1;30(1):46-52
J:30130 Lin TM, et al., Multiple functions of the TR2-11 orphan receptor in modulating activation of two key cis-acting elements involved in the retinoic acid signal transduction system. J Biol Chem. 1995 Dec 15;270(50):30121-8
J:34527 Lee CH, et al., Molecular cloning and characterization of a mouse nuclear orphan receptor expressed in embryos and testes. Mol Reprod Dev. 1996 Jul;44(3):305-14
J:38523 Lee CH, et al., Distinct expression patterns and biological activities of two isoforms of the mouse orphan receptor TR2. J Endocrinol. 1997 Feb;152(2):245-55
J:46502 Immervoll T, et al., Polymorphism in the murine Tr2-11 gene encoding an orphan receptor, and its exclusion as a candidate gene for the cataract mutation Cat3. Biol Chem. 1998 Jan;379(1):83-5
J:49143 Young WJ, et al., A bidirectional regulation between the TR2/TR4 orphan receptors (TR2/TR4) and the ciliary neurotrophic factor (CNTF) signaling pathway. J Biol Chem. 1998 Aug 14;273(33):20877-85
J:50521 Lee CH, et al., Cloning and characterization of mouse RIP140, a corepressor for nuclear orphan receptor TR2. Mol Cell Biol. 1998 Nov;18(11):6745-55
J:77023 Shyr CR, et al., Spermatogenesis and testis development are normal in mice lacking testicular orphan nuclear receptor 2. Mol Cell Biol. 2002 Jul;22(13):4661-6
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:113832 Chinpaisal C, et al., The orphan nuclear receptor TR2 suppresses a DR4 hormone response element of the mouse CRABP-I gene promoter. Biochemistry. 1997 Nov 18;36(46):14088-95
J:114039 Franco PJ, et al., The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases. Mol Endocrinol. 2001 Aug;15(8):1318-28
J:121628 Tanabe O, et al., Embryonic and fetal beta-globin gene repression by the orphan nuclear receptors, TR2 and TR4. EMBO J. 2007 May 2;26(9):2295-306
J:121895 Gupta P, et al., Orphan nuclear receptor TR2, a mediator of preadipocyte proliferation, is differentially regulated by RA through exchange of coactivator PCAF with corepressor RIP140 on a platform molecule GRIP1. Nucleic Acids Res. 2007;35(7):2269-82
J:126307 Tanabe O, et al., The TR2 and TR4 orphan nuclear receptors repress Gata1 transcription. Genes Dev. 2007 Nov 1;21(21):2832-44
J:151809 Shyr CR, et al., Roles of testicular orphan nuclear receptors 2 and 4 in early embryonic development and embryonic stem cells. Endocrinology. 2009 May;150(5):2454-62
J:158064 Gupta P, et al., HDAC3 as a molecular chaperone for shuttling phosphorylated TR2 to PML: a novel deacetylase activity-independent function of HDAC3. PLoS One. 2009;4(2):e4363
J:175152 Gupta P, et al., Retinoic acid-stimulated sequential phosphorylation, PML recruitment, and SUMOylation of nuclear receptor TR2 to suppress Oct4 expression. Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11424-9
J:175360 Khan SA, et al., Protein kinase C-mediated phosphorylation of orphan nuclear receptor TR2: effects on receptor stability and activity. Proteomics. 2005 Oct;5(15):3885-94
J:245382 Park SW, et al., SUMOylation of Tr2 orphan receptor involves Pml and fine-tunes Oct4 expression in stem cells. Nat Struct Mol Biol. 2007 Jan;14(1):68-75