Sequence Detail

ID/Version

Q4VGL6 B2RS13 Q69Z31 (UniProt | EBI)

Last sequence update: 2005-07-05
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Roquin-1 {ECO:0000305}; Short=Roquin {ECO:0000305}; EC=2.3.2.27 {ECO:0000250|UniProtKB:Q5TC82};AltName: Full=Protein Sanroque {ECO:0000303|PubMed:23583642};AltName: Full=RING finger and C3H zinc finger protein 1;AltName: Full

Provider

SWISS-PROT

Sequence

Polypeptide 1130 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Rc3h1	RING CCCH (C3H) domains 1	62	96	3	22

Sequence references in MGI

J:92575 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2004 Jun 30;11(3):205-18
J:98938 Vinuesa CG, et al., A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity. Nature. 2005 May 26;435(7041):452-8
J:162534 Glasmacher E, et al., Roquin binds inducible costimulator mRNA and effectors of mRNA decay to induce microRNA-independent post-transcriptional repression. Nat Immunol. 2010 Aug;11(8):725-33
J:175161 Yu D, et al., Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA. Nature. 2007 Nov 8;450(7167):299-303
J:177784 Bertossi A, et al., Loss of Roquin induces early death and immune deregulation but not autoimmunity. J Exp Med. 2011 Aug 29;208(9):1749-56
J:196136 Vogel KU, et al., Roquin Paralogs 1 and 2 Redundantly Repress the Icos and Ox40 Costimulator mRNAs and Control Follicular Helper T Cell Differentiation. Immunity. 2013 Apr 18;38(4):655-68
J:196137 Pratama A, et al., Roquin-2 Shares Functions with Its Paralog Roquin-1 in the Repression of mRNAs Controlling T Follicular Helper Cells and Systemic Inflammation. Immunity. 2013 Apr 18;38(4):669-80
J:199407 Schaefer JS, et al., Small intestine inflammation in Roquin-mutant and Roquin-deficient mice. PLoS One. 2013;8(2):e56436
J:221791 Srivastava M, et al., Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis. Nat Commun. 2015;6:6253
J:228359 Mino T, et al., Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms. Cell. 2015 May 21;161(5):1058-73
J:236832 Janowski R, et al., Roquin recognizes a non-canonical hexaloop structure in the 3'-UTR of Ox40. Nat Commun. 2016 Mar 24;7:11032
J:259145 Jeltsch KM, et al., Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T(H)17 differentiation. Nat Immunol. 2014 Nov;15(11):1079-89
J:261058 Schlundt A, et al., Structural basis for RNA recognition in roquin-mediated post-transcriptional gene regulation. Nat Struct Mol Biol. 2014 Aug;21(8):671-8
J:261340 Hanieh H, et al., Arid5a stabilizes OX40 mRNA in murine CD4(+) T cells by recognizing a stem-loop structure in its 3'UTR. Eur J Immunol. 2018 Apr;48(4):593-604
J:281595 Tavernier SJ, et al., A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation. Nat Commun. 2019 Oct 21;10(1):4779
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89