Sequence Detail

ID/Version

Q3UV55 Q3UJJ1 Q6EEZ6 Q922A5 Q9ESY4 Q62171 (UniProt | EBI)

Last sequence update: 2005-10-11
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=Nuclear receptor subfamily 1 group D member 1;AltName: Full=Rev-erbA-alpha;AltName: Full=V-erbA-related protein 1; Short=EAR-1;

Provider

SWISS-PROT

Sequence

Polypeptide 615 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nr1d1	nuclear receptor subfamily 1, group D, member 1	118	124	3	25

Sequence references in MGI

J:46724 Zamir I, et al., Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex. Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14400-5
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:134207 Wang J, et al., Bifunctional role of Rev-erbalpha in adipocyte differentiation. Mol Cell Biol. 2008 Apr;28(7):2213-20
J:141770 Duez H, et al., Regulation of bile acid synthesis by the nuclear receptor Rev-erbalpha. Gastroenterology. 2008 Aug;135(2):689-98
J:153064 Le Martelot G, et al., REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis. PLoS Biol. 2009 Sep;7(9):e1000181
J:156994 Schmutz I, et al., The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors. Genes Dev. 2010 Feb 15;24(4):345-57
J:161386 Yin L, et al., E3 ligases Arf-bp1 and Pam mediate lithium-stimulated degradation of the circadian heme receptor Rev-erb alpha. Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11614-9
J:171710 Mollema NJ, et al., Nuclear receptor Rev-erb alpha (Nr1d1) functions in concert with Nr2e3 to regulate transcriptional networks in the retina. PLoS One. 2011;6(3):e17494
J:179376 Lamia KA, et al., Cryptochromes mediate rhythmic repression of the glucocorticoid receptor. Nature. 2011 Dec 22;480(7378):552-6
J:179782 Valnegri P, et al., A circadian clock in hippocampus is regulated by interaction between oligophrenin-1 and Rev-erbalpha. Nat Neurosci. 2011 Oct;14(10):1293-301
J:180129 Gibbs JE, et al., The nuclear receptor REV-ERBalpha mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines. Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):582-7
J:181732 Vieira E, et al., The clock gene Rev-erbalpha regulates pancreatic beta-cell function: modulation by leptin and high-fat diet. Endocrinology. 2012 Feb;153(2):592-601
J:183623 Bugge A, et al., Rev-erbalpha and Rev-erbbeta coordinately protect the circadian clock and normal metabolic function. Genes Dev. 2012 Apr 1;26(7):657-67
J:198046 Chini CC, et al., DBC1 (Deleted in Breast Cancer 1) modulates the stability and function of the nuclear receptor Rev-erbalpha. Biochem J. 2013 May 1;451(3):453-61
J:198214 Barclay JL, et al., High-fat diet-induced hyperinsulinemia and tissue-specific insulin resistance in Cry-deficient mice. Am J Physiol Endocrinol Metab. 2013 May 15;304(10):E1053-63
J:200091 Woldt E, et al., Rev-erb-alpha modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy. Nat Med. 2013 Aug;19(8):1039-46
J:203422 Gerhart-Hines Z, et al., The nuclear receptor Rev-erbalpha controls circadian thermogenic plasticity. Nature. 2013 Nov 21;503(7476):410-3
J:205637 Negoro H, et al., Involvement of urinary bladder Connexin43 and the circadian clock in coordination of diurnal micturition rhythm. Nat Commun. 2012;3:809
J:207820 Curtis AM, et al., Histone acetyltransferase-dependent chromatin remodeling and the vascular clock. J Biol Chem. 2004 Feb 20;279(8):7091-7
J:211323 Xiao J, et al., Transcription factor NF-Y is a functional regulator of the transcription of core clock gene Bmal1. J Biol Chem. 2013 Nov 1;288(44):31930-6
J:244091 Noh JY, et al., Presence of multiple peripheral circadian oscillators in the tissues controlling voiding function in mice. Exp Mol Med. 2014 Mar 07;46:e81
J:247279 Okabe T, et al., REV-ERBalpha influences the stability and nuclear localization of the glucocorticoid receptor. J Cell Sci. 2016 Nov 01;129(21):4143-4154
J:264705 Pariollaud M, et al., Circadian clock component REV-ERBalpha controls homeostatic regulation of pulmonary inflammation. J Clin Invest. 2018 Jun 1;128(6):2281-2296
J:266073 Toledo M, et al., Autophagy Regulates the Liver Clock and Glucose Metabolism by Degrading CRY1. Cell Metab. 2018 Aug 7;28(2):268-281.e4
J:266297 Dyar KA, et al., Transcriptional programming of lipid and amino acid metabolism by the skeletal muscle circadian clock. PLoS Biol. 2018 Aug;16(8):e2005886
J:271692 Zhao X, et al., Circadian Amplitude Regulation via FBXW7-Targeted REV-ERBalpha Degradation. Cell. 2016 Jun 16;165(7):1644-1657
J:271698 Zhao M, et al., E4bp4 regulates carboxylesterase 2 enzymes through repression of the nuclear receptor Rev-erbalpha in mice. Biochem Pharmacol. 2018 Jun;152:293-301
J:271712 Zhang T, et al., Small Heterodimer Partner Regulates Circadian Cytochromes p450 and Drug-Induced Hepatotoxicity. Theranostics. 2018;8(19):5246-5258
J:273176 Griffin P, et al., Circadian clock protein Rev-erbalpha regulates neuroinflammation. Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):5102-5107
J:273537 Ohba Y, et al., Phosphorylation of N-terminal regions of REV-ERBs regulates their intracellular localization. Genes Cells. 2018 Apr;23(4):285-293
J:273552 Aninye IO, et al., Circadian regulation of Tshb gene expression by Rev-Erbalpha (NR1D1) and nuclear corepressor 1 (NCOR1). J Biol Chem. 2014 Jun 13;289(24):17070-7
J:274080 Lee SM, et al., Small heterodimer partner/neuronal PAS domain protein 2 axis regulates the oscillation of liver lipid metabolism. Hepatology. 2015 Feb;61(2):497-505
J:285015 Galmozzi A, et al., PGRMC2 is an intracellular haem chaperone critical for adipocyte function. Nature. 2019 Dec;576(7785):138-142
J:319841 Liu AC, et al., Redundant function of REV-ERBalpha and beta and non-essential role for Bmal1 cycling in transcriptional regulation of intracellular circadian rhythms. PLoS Genet. 2008 Feb 29;4(2):e1000023
J:356901 Lam MT, et al., Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription. Nature. 2013 Jun 27;498(7455):511-5