Sequence Detail

ID/Version

Q3UR85 B2RXQ7 Q3V3K4 F8WJJ9 (UniProt | EBI)

Last sequence update: 2008-02-26
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Myelin regulatory factor; EC=3.4.-.- {ECO:0000269|PubMed:23966833, ECO:0000269|PubMed:28623291};AltName: Full=Myelin gene regulatory factor;Contains: RecName: Full=Myelin regulatory factor, N-terminal;Contains: RecName: Full=Myelin

Provider

SWISS-PROT

Sequence

Polypeptide 1138 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Myrf	myelin regulatory factor	35	105	3	52

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:150563 Emery B, et al., Myelin gene regulatory factor is a critical transcriptional regulator required for CNS myelination. Cell. 2009 Jul 10;138(1):172-85
J:187678 Koenning M, et al., Myelin gene regulatory factor is required for maintenance of myelin and mature oligodendrocyte identity in the adult CNS. J Neurosci. 2012 Sep 5;32(36):12528-42
J:201590 Bujalka H, et al., MYRF is a membrane-associated transcription factor that autoproteolytically cleaves to directly activate myelin genes. PLoS Biol. 2013 Aug;11(8):e1001625
J:205136 Hornig J, et al., The transcription factors Sox10 and Myrf define an essential regulatory network module in differentiating oligodendrocytes. PLoS Genet. 2013 Oct;9(10):e1003907
J:236148 Muth KN, et al., The Dual-specificity phosphatase Dusp15 is regulated by Sox10 and Myrf in Myelinating Oligodendrocytes. Glia. 2016 Dec;64(12):2120-2132
J:267268 Huang H, et al., Interactive Repression of MYRF Self-Cleavage and Activity in Oligodendrocyte Differentiation by TMEM98 Protein. J Neurosci. 2018 Nov 14;38(46):9829-9839
J:276408 Meng J, et al., Myrf ER-Bound Transcription Factors Drive C. elegans Synaptic Plasticity via Cleavage-Dependent Nuclear Translocation. Dev Cell. 2017 Apr 24;41(2):180-194.e7