Sequence Detail

ID/Version

Q3UQS8 E9PVK0 Q8CFS9 (UniProt | EBI)

Last sequence update: 2012-10-31
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=RNA-binding protein 20 {ECO:0000305};AltName: Full=RNA-binding motif protein 20 {ECO:0000305};

Provider

SWISS-PROT

Sequence

Polypeptide 1199 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Rbm20	RNA binding motif protein 20	58	99	3	21

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:188888 Guo W, et al., RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing. Nat Med. 2012 May;18(5):766-73
J:201907 Filippello A, et al., Identification of nuclear retention domains in the RBM20 protein. FEBS Lett. 2013 Sep 17;587(18):2989-95
J:210662 Beraldi R, et al., Rbm20-deficient cardiogenesis reveals early disruption of RNA processing and sarcomere remodeling establishing a developmental etiology for dilated cardiomyopathy. Hum Mol Genet. 2014 Jul 15;23(14):3779-91
J:237830 Methawasin M, et al., Experimentally Increasing the Compliance of Titin Through RNA Binding Motif-20 (RBM20) Inhibition Improves Diastolic Function In a Mouse Model of Heart Failure With Preserved Ejection Fraction. Circulation. 2016 Oct 11;134(15):1085-1099
J:263135 Murayama R, et al., Phosphorylation of the RSRSP stretch is critical for splicing regulation by RNA-Binding Motif Protein 20 (RBM20) through nuclear localization. Sci Rep. 2018 Jun 12;8(1):8970
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:297234 Ihara K, et al., A missense mutation in the RSRSP stretch of Rbm20 causes dilated cardiomyopathy and atrial fibrillation in mice. Sci Rep. 2020 Oct 27;10(1):17894
J:302931 van den Hoogenhof MMG, et al., RBM20 Mutations Induce an Arrhythmogenic Dilated Cardiomyopathy Related to Disturbed Calcium Handling. Circulation. 2018 Sep 25;138(13):1330-1342
J:324088 Wang C, et al., RBM20(S639G) mutation is a high genetic risk factor for premature death through RNA-protein condensates. J Mol Cell Cardiol. 2022 Jan 15;165:115-129
J:324091 Upadhyay SK, et al., Structural basis of UCUU RNA motif recognition by splicing factor RBM20. Nucleic Acids Res. 2020 May 7;48(8):4538-4550
J:324125 Zhang Y, et al., RBM20 phosphorylation and its role in nucleocytoplasmic transport and cardiac pathogenesis. FASEB J. 2022 May;36(5):e22302
J:338015 Montanes-Agudo P, et al., Quaking regulates circular RNA production in cardiomyocytes. J Cell Sci. 2023 Jul 1;136(13)