Sequence Detail

ID/Version

Q3UMW7 Q3T9E6 E9QNE1 B0QZU7 Q8K0G3 (UniProt | EBI)

Last sequence update: 2005-12-06
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=MAP kinase-activated protein kinase 3; Short=MAPK-activated protein kinase 3; Short=MAPKAP kinase 3; Short=MAPKAP-K3; Short=MAPKAPK-3; Short=MK-3; EC=2.7.11.1;

Provider

SWISS-PROT

Sequence

Polypeptide 384 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mapkapk3	mitogen-activated protein kinase-activated protein kinase 3	24	101	3	20

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:117668 Ronkina N, et al., The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK. Mol Cell Biol. 2007 Jan;27(1):170-81
J:126340 Zaru R, et al., The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways. Nat Immunol. 2007 Nov;8(11):1227-35
J:166791 Menon MB, et al., p38 MAP kinase and MAPKAP kinases MK2/3 cooperatively phosphorylate epithelial keratins. J Biol Chem. 2010 Oct 22;285(43):33242-51
J:229470 Meunier I, et al., A dominant mutation in MAPKAPK3, an actor of p38 signaling pathway, causes a new retinal dystrophy involving Bruch's membrane and retinal pigment epithelium. Hum Mol Genet. 2016 Mar 1;25(5):916-26