Sequence Detail

ID/Version

Q3UMR5 B2RTD1 Q3TTK3 (UniProt | EBI)

Last sequence update: 2007-04-03
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Calcium uniporter protein, mitochondrial {ECO:0000305};Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 350 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mcu	mitochondrial calcium uniporter	78	102	3	24

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:174847 De Stefani D, et al., A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter. Nature. 2011 Aug 18;476(7360):336-40
J:174848 Baughman JM, et al., Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter. Nature. 2011 Aug 18;476(7360):341-5
J:196142 Rardin MJ, et al., Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6
J:196299 Plovanich M, et al., MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handling. PLoS One. 2013;8(2):e55785
J:201635 Raffaello A, et al., The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit. EMBO J. 2013 Aug 28;32(17):2362-76
J:208297 Pan X, et al., The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter. Nat Cell Biol. 2013 Dec;15(12):1464-72
J:219717 Wu Y, et al., The mitochondrial uniporter controls fight or flight heart rate increases. Nat Commun. 2015;6:6081
J:224853 Kwong JQ, et al., The Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the Heart. Cell Rep. 2015 Jul 7;12(1):15-22
J:224856 Luongo TS, et al., The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition. Cell Rep. 2015 Jul 7;12(1):23-34
J:225748 Holmstrom KM, et al., Assessment of cardiac function in mice lacking the mitochondrial calcium uniporter. J Mol Cell Cardiol. 2015 Aug;85:178-82
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89