Sequence Detail

ID/Version

Q3ULA2 Q9R1G7 Q9QUI5 Q9Z159 Q571K6 Q3U0Q4 (UniProt | EBI)

Last sequence update: 2010-04-20
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=F-box/WD repeat-containing protein 1A {ECO:0000250|UniProtKB:Q9Y297, ECO:0000312|EMBL:AAL40929.1};AltName: Full=Beta-TrCP protein E3RS-IkappaB {ECO:0000312|EMBL:AAD08701.1};AltName: Full=Beta-transducin repeat-containing protein {ECO:0000312

Provider

SWISS-PROT

Sequence

Polypeptide 605 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Btrc	beta-transducin repeat containing protein	96	109	2	31

Sequence references in MGI

J:53039 Spencer E, et al., Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP. Genes Dev. 1999 Feb 1;13(3):284-94
J:54020 Hatakeyama S, et al., Ubiquitin-dependent degradation of IkappaBalpha is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3859-63
J:54317 Yaron A, et al., Identification of the receptor component of the IkappaBalpha-ubiquitin ligase. Nature. 1998 Dec 10;396(6711):590-4
J:58149 Winston JT, et al., A family of mammalian F-box proteins. Curr Biol. 1999 Oct 21;9(20):1180-2
J:73276 Maruyama S, et al., Characterization of a mouse gene (Fbxw6) that encodes a homologue of Caenorhabditis elegans SEL-10. Genomics. 2001 Dec;78(3):214-22
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:166433 Ohsaki K, et al., The role of {beta}-TrCP1 and {beta}-TrCP2 in circadian rhythm generation by mediating degradation of clock protein PER2. J Biochem. 2008 Nov;144(5):609-18
J:169903 Wang B, et al., Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing. Proc Natl Acad Sci U S A. 2006 Jan 3;103(1):33-8
J:178646 Tsuchiya Y, et al., Dual regulation of the transcriptional activity of Nrf1 by beta-TrCP- and Hrd1-dependent degradation mechanisms. Mol Cell Biol. 2011 Nov;31(22):4500-12
J:179016 Iwasaki H, et al., The IkappaB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1. Nat Immunol. 2011 Dec;12(12):1167-75
J:209489 Shirogane T, et al., SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein. J Biol Chem. 2005 Jul 22;280(29):26863-72
J:259707 Ye B, et al., Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice. Nat Commun. 2018 Mar 28;9(1):1261