Sequence Detail

ID/Version

Q3UHN9 O70353 Q3TBX3 Q9R206 Q8BZE5 Q3TDS3 (UniProt | EBI)

Last sequence update: 2006-03-07
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 {ECO:0000305|PubMed:10758005};AltName: Full=Glucosaminyl N-deacetylase/N-sulfotransferase 1; Short=NDST-1 {ECO:0000303|PubMed:10758005};AltName: Full=N-heparan sulfate s

Provider

SWISS-PROT

Sequence

Polypeptide 882 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	70	107	4	11

Sequence references in MGI

J:47442 Kusche-Gullberg M, et al., Identification and expression in mouse of two heparan sulfate glucosaminyl N-deacetylase/N-sulfotransferase genes. J Biol Chem. 1998 May 8;273(19):11902-7
J:60280 Fan G, et al., Targeted disruption of NDST-1 gene leads to pulmonary hypoplasia and neonatal respiratory distress in mice. FEBS Lett. 2000 Feb 4;467(1):7-11
J:63996 Ringvall M, et al., Defective heparan sulfate biosynthesis and neonatal lethality in mice lacking N-deacetylase/N-sulfotransferase-1. J Biol Chem. 2000 Aug 25;275(34):25926-30
J:67535 Aikawa J, et al., Multiple isozymes of heparan sulfate/heparin GlcNAc N-deacetylase/GlcN N-sulfotransferase. Structure and activity of the fourth member, NDST4. J Biol Chem. 2001 Feb 23;276(8):5876-82
J:83789 Jenniskens GJ, et al., Disturbed Ca2+ kinetics in N-deacetylase/N-sulfotransferase-1 defective myotubes. J Cell Sci. 2003 Jun 1;116(Pt 11):2187-93
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:100425 Grobe K, et al., Cerebral hypoplasia and craniofacial defects in mice lacking heparan sulfate Ndst1 gene function. Development. 2005 Aug;132(16):3777-86
J:100456 Wang L, et al., Endothelial heparan sulfate deficiency impairs L-selectin- and chemokine-mediated neutrophil trafficking during inflammatory responses. Nat Immunol. 2005 Sep;6(9):902-10
J:133353 Presto J, et al., Heparan sulfate biosynthesis enzymes EXT1 and EXT2 affect NDST1 expression and heparan sulfate sulfation. Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4751-6
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:319995 van den Born J, et al., Antibody-based assay for N-deacetylase activity of heparan sulfate/heparin N-deacetylase/N-sulfotransferase (NDST): novel characteristics of NDST-1 and -2. Glycobiology. 2003 Jan;13(1):1-10
J:320263 Pikas DS, et al., Overexpression of different isoforms of glucosaminyl N-deacetylase/N-sulfotransferase results in distinct heparan sulfate N-sulfation patterns. Biochemistry. 2000 Apr 18;39(15):4552-8