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Sequence Detail
Q3UHC7 Q3UH44 Q80T97 A2AUW9 A5X2X2 A2AUX2 B7ZD28 Q6Y636 Q3TPD5 Q6JTV1 (UniProt | EBI) Last sequence update: 2005-10-11
Last annotation update: 2019-05-08
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RecName: Full=Disabled homolog 2-interacting protein; Short=DAB2-interacting protein;AltName: Full=ASK-interacting protein 1;AltName: Full=DOC-2/DAB-2 interactive protein;
Polypeptide 1189 aa
For this sequence
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Orthologs Phenotypic
Gene Dab2ip disabled 2 interacting protein 127 4 9 54
Sequence references in MGI J:83413 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Feb 28;10(1):35-48
J:85094 Homayouni R, et al., Interaction of Disabled-1 and the GTPase activating protein Dab2IP in mouse brain. Brain Res Mol Brain Res. 2003 Jul 23;115(2):121-9
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:127632 Chen H, et al., Cloning of mouse Dab2ip gene, a novel member of the RasGTPase-activating protein family and characterization of its regulatory region in prostate. DNA Cell Biol. 2006 Apr;25(4):232-45
J:136554 Luo D, et al., AIP1 is critical in transducing IRE1-mediated endoplasmic reticulum stress response. J Biol Chem. 2008 May 2;283(18):11905-12
J:144734 Zhang H, et al., AIP1 functions as an endogenous inhibitor of VEGFR2-mediated signaling and inflammatory angiogenesis in mice. J Clin Invest. 2008 Dec;118(12):3904-16
J:154743 Xie D, et al., DAB2IP coordinates both PI3K-Akt and ASK1 pathways for cell survival and apoptosis. Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):19878-83
J:157597 Xie D, et al., Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis. Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2485-90
J:159941 Wan T, et al., AIP1 functions as Arf6-GAP to negatively regulate TLR4 signaling. J Biol Chem. 2010 Feb 5;285(6):3750-7
J:168268 Min J, et al., An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB. Nat Med. 2010 Mar;16(3):286-94
J:186600 Yu L, et al., AIP1 prevents graft arteriosclerosis by inhibiting interferon-gamma-dependent smooth muscle cell proliferation and intimal expansion. Circ Res. 2011 Aug 5;109(4):418-27
J:191935 Lee GH, et al., Dab2ip regulates neuronal migration and neurite outgrowth in the developing neocortex. PLoS One. 2012;7(10):e46592
J:195873 Qiao S, et al., Dab2IP GTPase activating protein regulates dendrite development and synapse number in cerebellum. PLoS One. 2013;8(1):e53635

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
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