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Sequence Detail
Q3UCV8 Q5M8N1 Q8R027 Q3UY59 (UniProt | EBI) Last sequence update: 2005-10-11
Last annotation update: 2019-07-31
from provider
RecName: Full=Ubiquitin thioesterase otulin {ECO:0000305}; EC= {ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:29950720};AltName: Full=Deubiquitinating enzyme otulin {ECO:0000250|UniProtKB:Q96BN8};AltName: Full=OTU domain-containing deub
Polypeptide 352 aa
For this sequence
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Orthologs Phenotypic
Gene Otulin OTU deubiquitinase with linear linkage specificity 34 7 10 9
Sequence references in MGI J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:197674 Rivkin E, et al., The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis. Nature. 2013 Jun 20;498(7454):318-24
J:236075 Damgaard RB, et al., The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity. Cell. 2016 Aug 25;166(5):1215-1230.e20
J:264084 Heger K, et al., OTULIN limits cell death and inflammation by deubiquitinating LUBAC. Nature. 2018 Jul;559(7712):120-124

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory