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Sequence Detail
Q3U9G9 Q8BST3 Q91Z27 Q811V9 Q811V8 Q3TSW2 Q8VDM0 Q91YS5 Q8K2Y8 (UniProt | EBI) Last sequence update: 2006-03-21
Last annotation update: 2019-12-11
from provider
RecName: Full=Delta(14)-sterol reductase LBR; Short=Delta-14-SR; EC= {ECO:0000250|UniProtKB:Q14739};AltName: Full=3-beta-hydroxysterol Delta (14)-reductase {ECO:0000303|PubMed:18785926};AltName: Full=C-14 sterol reductase;
Polypeptide 626 aa
For this sequence
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Orthologs Phenotypic
Gene Lbr lamin B receptor 37 3 8 33
Sequence references in MGI J:80915 Shultz LD, et al., Mutations at the mouse ichthyosis locus are within the lamin B receptor gene: a single gene model for human Pelger-Huet anomaly. Hum Mol Genet. 2003 Jan 1;12(1):61-9
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:143116 Bennati AM, et al., Disruption of the gene encoding 3beta-hydroxysterol Delta-reductase (Tm7sf2) in mice does not impair cholesterol biosynthesis. FEBS J. 2008 Oct;275(20):5034-47
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:180894 Subramanian G, et al., Lamin B receptor regulates the growth and maturation of myeloid progenitors via its sterol reductase domain: implications for cholesterol biosynthesis in regulating myelopoiesis. J Immunol. 2012 Jan 1;188(1):85-102
J:277871 Xu M, et al., Clnk plays a role in TNF-alpha-induced cell death in murine fibrosarcoma cell line L929. Biochem Biophys Res Commun. 2015 Jul 31;463(3):275-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory