Sequence Detail

ID/Version

Q3U8K7 Q8BUN0 Q3UTP6 Q6Q784 Q8BZ24 Q8BU67 Q8BUT7 Q8BW73 Q91X81 Q6DI74 (UniProt | EBI)

Last sequence update: 2007-04-03
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Histone-lysine N-methyltransferase KMT5B {ECO:0000305};AltName: Full=Lysine-specific methyltransferase 5B {ECO:0000250|UniProtKB:Q4FZB7};AltName: Full=Suppressor of variegation 4-20 homolog 1; Short=Su(var)4-20 homolog 1; Sho

Provider

SWISS-PROT

Sequence

Polypeptide 883 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Kmt5b	lysine methyltransferase 5B	51	100	3	25

Sequence references in MGI

J:90491 Schotta G, et al., A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev. 2004 Jun 1;18(11):1251-62
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:108366 Isaac CE, et al., The retinoblastoma protein regulates pericentric heterochromatin. Mol Cell Biol. 2006 May;26(9):3659-71
J:211428 Southall SM, et al., A novel route to product specificity in the Suv4-20 family of histone H4K20 methyltransferases. Nucleic Acids Res. 2014 Jan;42(1):661-71
J:244069 Neguembor MV, et al., FSHD muscular dystrophy region gene 1 binds Suv4-20h1 histone methyltransferase and impairs myogenesis. J Mol Cell Biol. 2013 Oct;5(5):294-307
J:280470 Bromberg KD, et al., The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity. Nat Chem Biol. 2017 Mar;13(3):317-324