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Sequence Detail
Q3U6B2 Q7TMV7 Q80T40 Q3U1F6 (UniProt | EBI) Last sequence update: 2005-10-11
Last annotation update: 2018-11-07
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RecName: Full=G-protein coupled receptor 183 {ECO:0000305};AltName: Full=Epstein-Barr virus-induced G-protein coupled receptor 2 homolog {ECO:0000250|UniProtKB:P32249}; Short=EBI2 {ECO:0000250|UniProtKB:P32249}; Short=EBV-induced G-protein
Polypeptide 357 aa
For this sequence
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Orthologs Phenotypic
Gene Gpr183 G protein-coupled receptor 183 27 3 10 9
Sequence references in MGI J:83410 Vassilatis DK, et al., The G protein-coupled receptor repertoires of human and mouse. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4903-8
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:151077 Pereira JP, et al., EBI2 mediates B cell segregation between the outer and centre follicle. Nature. 2009 Aug 27;460(7259):1122-6
J:151883 Gatto D, et al., Guidance of B cells by the orphan G protein-coupled receptor EBI2 shapes humoral immune responses. Immunity. 2009 Aug 21;31(2):259-69
J:174682 Hannedouche S, et al., Oxysterols direct immune cell migration via EBI2. Nature. 2011 Jul 28;475(7357):524-7
J:174683 Liu C, et al., Oxysterols direct B-cell migration through EBI2. Nature. 2011 Jul 28;475(7357):519-23
J:179238 Kelly LM, et al., EBI2 guides serial movements of activated B cells and ligand activity is detectable in lymphoid and nonlymphoid tissues. J Immunol. 2011 Sep 15;187(6):3026-32
J:179449 Gatto D, et al., EBI2 operates independently of but in cooperation with CXCR5 and CCR7 to direct B cell migration and organization in follicles and the germinal center. J Immunol. 2011 Nov 1;187(9):4621-8
J:186017 Benned-Jensen T, et al., Ligand modulation of the Epstein-Barr virus-induced seven-transmembrane receptor EBI2: identification of a potent and efficacious inverse agonist. J Biol Chem. 2011 Aug 19;286(33):29292-302
J:196453 Gatto D, et al., The chemotactic receptor EBI2 regulates the homeostasis, localization and immunological function of splenic dendritic cells. Nat Immunol. 2013 May;14(5):446-53
J:198681 Yi T, et al., EBI2-mediated bridging channel positioning supports splenic dendritic cell homeostasis and particulate antigen capture. Elife. 2013;2:e00757
J:218092 Rutkowska A, et al., EBI2 regulates intracellular signaling and migration in human astrocyte. Glia. 2015 Feb;63(2):341-51
J:229030 Nevius E, et al., Oxysterols and EBI2 promote osteoclast precursor migration to bone surfaces and regulate bone mass homeostasis. J Exp Med. 2015 Oct 19;212(11):1931-46
J:233676 Li J, et al., EBI2 augments Tfh cell fate by promoting interaction with IL-2-quenching dendritic cells. Nature. 2016 May 5;533(7601):110-4
J:243904 Huang C, et al., The BCL6 RD2 domain governs commitment of activated B cells to form germinal centers. Cell Rep. 2014 Sep 11;8(5):1497-508

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last database update
MGI 6.13
The Jackson Laboratory