ID/Version |
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Sequence description from provider |
RecName: Full=G-protein coupled receptor 183 {ECO:0000305};AltName: Full=Epstein-Barr virus-induced G-protein coupled receptor 2 homolog {ECO:0000250|UniProtKB:P32249}; Short=EBI2 {ECO:0000250|UniProtKB:P32249}; Short=EBV-induced G-protein | ||||||||||||||
Provider | SWISS-PROT | ||||||||||||||
Sequence |
Polypeptide
357
aa
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Annotated genes and markers |
Follow the symbol links to get more information on the GO terms,
expression assays, orthologs, phenotypic alleles, and other information
for the genes or markers below.
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Sequence references in MGI |
J:83410
Vassilatis DK, et al., The G protein-coupled receptor repertoires of human and mouse. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4903-8
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563 J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54 J:151077 Pereira JP, et al., EBI2 mediates B cell segregation between the outer and centre follicle. Nature. 2009 Aug 27;460(7259):1122-6 J:151883 Gatto D, et al., Guidance of B cells by the orphan G protein-coupled receptor EBI2 shapes humoral immune responses. Immunity. 2009 Aug 21;31(2):259-69 J:174682 Hannedouche S, et al., Oxysterols direct immune cell migration via EBI2. Nature. 2011 Jul 28;475(7357):524-7 J:174683 Liu C, et al., Oxysterols direct B-cell migration through EBI2. Nature. 2011 Jul 28;475(7357):519-23 J:179238 Kelly LM, et al., EBI2 guides serial movements of activated B cells and ligand activity is detectable in lymphoid and nonlymphoid tissues. J Immunol. 2011 Sep 15;187(6):3026-32 J:179449 Gatto D, et al., EBI2 operates independently of but in cooperation with CXCR5 and CCR7 to direct B cell migration and organization in follicles and the germinal center. J Immunol. 2011 Nov 1;187(9):4621-8 J:186017 Benned-Jensen T, et al., Ligand modulation of the Epstein-Barr virus-induced seven-transmembrane receptor EBI2: identification of a potent and efficacious inverse agonist. J Biol Chem. 2011 Aug 19;286(33):29292-302 J:196453 Gatto D, et al., The chemotactic receptor EBI2 regulates the homeostasis, localization and immunological function of splenic dendritic cells. Nat Immunol. 2013 May;14(5):446-53 J:198681 Yi T, et al., EBI2-mediated bridging channel positioning supports splenic dendritic cell homeostasis and particulate antigen capture. Elife. 2013;2:e00757 J:218092 Rutkowska A, et al., EBI2 regulates intracellular signaling and migration in human astrocyte. Glia. 2015 Feb;63(2):341-51 J:229030 Nevius E, et al., Oxysterols and EBI2 promote osteoclast precursor migration to bone surfaces and regulate bone mass homeostasis. J Exp Med. 2015 Oct 19;212(11):1931-46 J:233676 Li J, et al., EBI2 augments Tfh cell fate by promoting interaction with IL-2-quenching dendritic cells. Nature. 2016 May 5;533(7601):110-4 J:243904 Huang C, et al., The BCL6 RD2 domain governs commitment of activated B cells to form germinal centers. Cell Rep. 2014 Sep 11;8(5):1497-508 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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