Sequence Detail

ID/Version

Q3U2S8 Q9DCE4 (UniProt | EBI)

Last sequence update: 2008-07-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Voltage-gated hydrogen channel 1;AltName: Full=Hydrogen voltage-gated channel 1; Short=HV1 {ECO:0000303|PubMed:20026664};AltName: Full=Voltage sensor domain-only protein {ECO:0000303|PubMed:16556803}; Short=mVSOP {ECO:0000303

Provider

SWISS-PROT

Sequence

Polypeptide 269 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Hvcn1	hydrogen voltage-gated channel 1	38	97	3	33

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:108335 Sasaki M, et al., A voltage sensor-domain protein is a voltage-gated proton channel. Science. 2006 Apr 28;312(5773):589-92
J:153699 Morgan D, et al., Voltage-gated proton channels maintain pH in human neutrophils during phagocytosis. Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):18022-7
J:156823 El Chemaly A, et al., VSOP/Hv1 proton channels sustain calcium entry, neutrophil migration, and superoxide production by limiting cell depolarization and acidification. J Exp Med. 2010 Jan 18;207(1):129-39, S1-2
J:206054 Fujiwara Y, et al., Gating of the designed trimeric/tetrameric voltage-gated H+ channel. J Physiol. 2013 Feb 1;591(Pt 3):627-40
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:345000 El Chemaly A, et al., Hv1 proton channels differentially regulate the pH of neutrophil and macrophage phagosomes by sustaining the production of phagosomal ROS that inhibit the delivery of vacuolar ATPases. J Leukoc Biol. 2014 May;95(5):827-839
J:345041 Fujiwara Y, et al., The cytoplasmic coiled-coil mediates cooperative gating temperature sensitivity in the voltage-gated H(+) channel Hv1. Nat Commun. 2012 May 8;3:816