Sequence Detail

ID/Version

Q3U1F9 Q8BFS1 Q9EQF3 (UniProt | EBI)

Last sequence update: 2005-12-20
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Phosphoprotein associated with glycosphingolipid-enriched microdomains 1;AltName: Full=Csk-binding protein;AltName: Full=Transmembrane phosphoprotein Cbp;

Provider

SWISS-PROT

Sequence

Polypeptide 429 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pag1	phosphoprotein associated with glycosphingolipid microdomains 1	28	99	3	9

Sequence references in MGI

J:71006 Brdicka T, et al., Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation. J Exp Med. 2000 May 1;191(9):1591-604
J:88290 Zhang SQ, et al., Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment. Mol Cell. 2004 Feb 13;13(3):341-55
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:101365 Xu S, et al., Cbp deficiency alters Csk localization in lipid rafts but does not affect T-cell development. Mol Cell Biol. 2005 Oct;25(19):8486-95
J:112254 Yasuda K, et al., Cutting edge: Fyn is essential for tyrosine phosphorylation of Csk-binding protein/phosphoprotein associated with glycolipid-enriched microdomains in lipid rafts in resting T cells. J Immunol. 2002 Sep 15;169(6):2813-7
J:113969 Davidson D, et al., Phosphorylation-dependent regulation of T-cell activation by PAG/Cbp, a lipid raft-associated transmembrane adaptor. Mol Cell Biol. 2003 Mar;23(6):2017-28
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89