Sequence Detail

ID/Version

Q3TYX3 Q91YL6 Q3TRB2 (UniProt | EBI)

Last sequence update: 2006-03-21
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Protein-lysine N-trimethyltransferase SMYD5 {ECO:0000305}; EC=2.1.1.- {ECO:0000250|UniProtKB:Q6GMV2};AltName: Full=Protein NN8-4AG;AltName: Full=Retinoic acid-induced protein 15 {ECO:0000303|PubMed:8754834};AltName: Full=SET and MYND

Provider

SWISS-PROT

Sequence

Polypeptide 416 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Smyd5	SET and MYND domain containing 5	31	100	3	23

Sequence references in MGI

J:34386 Shago M, et al., Isolation of a novel retinoic acid-responsive gene by selection of genomic fragments derived from CpG-island-enriched DNA. Mol Cell Biol. 1996 Aug;16(8):4337-48
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:306582 Stender JD, et al., Control of proinflammatory gene programs by regulated trimethylation and demethylation of histone H4K20. Mol Cell. 2012 Oct 12;48(1):28-38
J:306882 Kidder BL, et al., SMYD5 regulates H4K20me3-marked heterochromatin to safeguard ES cell self-renewal and prevent spurious differentiation. Epigenetics Chromatin. 2017;10:8
J:306885 Kidder BL, et al., SMYD5 Controls Heterochromatin and Chromosome Integrity during Embryonic Stem Cell Differentiation. Cancer Res. 2017 Dec 1;77(23):6729-6745
J:355642 Zhang Y, et al., SMYD5 catalyzes histone H3 lysine 36 trimethylation at promoters. Nat Commun. 2022 Jun 9;13(1):3190
J:355643 Rafnsdottir S, et al., SMYD5 is a regulator of the mild hypothermia response. Cell Rep. 2024 Aug 27;43(8):114554
J:357730 Miao B, et al., SMYD5 is a ribosomal methyltransferase that catalyzes RPL40 lysine methylation to enhance translation output and promote hepatocellular carcinoma. Cell Res. 2024 Sep;34(9):648-660
J:357741 Park J, et al., SMYD5 methylation of rpL40 links ribosomal output to gastric cancer. Nature. 2024 Aug;632(8025):656-663