Sequence Detail

ID/Version

Q3TXX4 E9QMT8 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Vesicular glutamate transporter 1 {ECO:0000303|PubMed:15103023}; Short=VGluT1 {ECO:0000303|PubMed:15103023};AltName: Full=Brain-specific Na(+)-dependent inorganic phosphate cotransporter {ECO:0000250|UniProtKB:Q62634};AltName: Full=S

Provider

SWISS-PROT

Sequence

Polypeptide 560 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Slc17a7	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7	86	134	4	19

Sequence references in MGI

J:89958 Wojcik SM, et al., An essential role for vesicular glutamate transporter 1 (VGLUT1) in postnatal development and control of quantal size. Proc Natl Acad Sci U S A. 2004 May 4;101(18):7158-63
J:91392 Schafer MK, et al., Molecular cloning and functional identification of mouse vesicular glutamate transporter 3 and its expression in subsets of novel excitatory neurons. J Biol Chem. 2002 Dec 27;277(52):50734-48
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:105647 Fremeau RT Jr, et al., Vesicular glutamate transporters 1 and 2 target to functionally distinct synaptic release sites. Science. 2004 Jun 18;304(5678):1815-9
J:113744 Yelamanchili SV, et al., Differential sorting of the vesicular glutamate transporter 1 into a defined vesicular pool is regulated by light signaling involving the clock gene Period2. J Biol Chem. 2006 Jun 9;281(23):15671-9
J:122985 Johnson J, et al., Vesicular glutamate transporter 1 is required for photoreceptor synaptic signaling but not for intrinsic visual functions. J Neurosci. 2007 Jul 4;27(27):7245-55
J:201867 Han K, et al., SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties. Nature. 2013 Nov 7;503(7474):72-7
J:256525 Martineau M, et al., VGLUT1 functions as a glutamate/proton exchanger with chloride channel activity in hippocampal glutamatergic synapses. Nat Commun. 2017 Dec 22;8(1):2279
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:311401 Cheret C, et al., Vesicular Glutamate Transporters (SLCA17 A6, 7, 8) Control Synaptic Phosphate Levels. Cell Rep. 2021 Jan 12;34(2):108623
J:324087 Preobraschenski J, et al., Vesicular glutamate transporters use flexible anion and cation binding sites for efficient accumulation of neurotransmitter. Neuron. 2014 Dec 17;84(6):1287-301
J:324193 Preobraschenski J, et al., Dual and Direction-Selective Mechanisms of Phosphate Transport by the Vesicular Glutamate Transporter. Cell Rep. 2018 Apr 10;23(2):535-545