Sequence Detail

ID/Version

Q3TBT3 Q3TZY8 Q8C227 Q8K393 A7YGY9 Q9CZY7 Q3TYP5 Q3TAV5 Q8C5Q3 Q3UJW3 (UniProt | EBI)

Last sequence update: 2008-11-25
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Stimulator of interferon genes protein {ECO:0000303|PubMed:18724357, ECO:0000303|PubMed:19776740}; Short=mSTING {ECO:0000303|PubMed:18724357, ECO:0000303|PubMed:19776740, ECO:0000303|PubMed:25636800};AltName: Full=Endoplasmic reticul

Provider

SWISS-PROT

Sequence

Polypeptide 378 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Sting1	stimulator of interferon response cGAMP interactor 1	160	102	3	52

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:139751 Jin L, et al., MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals. Mol Cell Biol. 2008 Aug;28(16):5014-26
J:141011 Ishikawa H, et al., STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Nature. 2008 Oct 2;455(7213):674-8
J:150011 Sun W, et al., ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization. Proc Natl Acad Sci U S A. 2009 May 26;106(21):8653-8
J:153502 Ishikawa H, et al., STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity. Nature. 2009 Oct 8;461(7265):788-92
J:176439 Zhang Z, et al., The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells. Nat Immunol. 2011;12(10):959-65
J:196209 Wu J, et al., Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science. 2013 Feb 15;339(6121):826-30
J:196251 Burdette DL, et al., STING is a direct innate immune sensor of cyclic di-GMP. Nature. 2011 Oct 27;478(7370):515-8
J:198729 Ablasser A, et al., cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING. Nature. 2013 Jun 20;498(7454):380-4
J:227350 Kranzusch PJ, et al., Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling. Mol Cell. 2015 Sep 17;59(6):891-903
J:233616 Zhang H, et al., Rat and human STINGs profile similarly towards anticancer/antiviral compounds. Sci Rep. 2015;5:18035
J:239879 Mukai K, et al., Activation of STING requires palmitoylation at the Golgi. Nat Commun. 2016 Jun 21;7:11932
J:249176 Moretti J, et al., STING Senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum. Cell. 2017 Nov 02;171(4):809-823.e13
J:259271 Hu MM, et al., Sumoylation Promotes the Stability of the DNA Sensor cGAS and the Adaptor STING to Regulate the Kinetics of Response to DNA Virus. Immunity. 2016 Sep 20;45(3):555-569
J:263151 Bridgeman A, et al., Viruses transfer the antiviral second messenger cGAMP between cells. Science. 2015 Sep 11;349(6253):1228-32
J:274853 Liu D, et al., STING directly activates autophagy to tune the innate immune response. Cell Death Differ. 2018 Dec 19;
J:283622 Wang L, et al., Nuclear hnRNPA2B1 initiates and amplifies the innate immune response to DNA viruses. Science. 2019 Aug 16;365(6454)
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:314549 Gao P, et al., Structure-function analysis of STING activation by c[G(2',5')pA(3',5')p] and targeting by antiviral DMXAA. Cell. 2013 Aug 15;154(4):748-62
J:319678 Haag SM, et al., Targeting STING with covalent small-molecule inhibitors. Nature. 2018 Jul;559(7713):269-273
J:319688 Takahama M, et al., The RAB2B-GARIL5 Complex Promotes Cytosolic DNA-Induced Innate Immune Responses. Cell Rep. 2017 Sep 19;20(12):2944-2954
J:342344 Ma M, et al., TAK1 is an essential kinase for STING trafficking. Mol Cell. 2023 Nov 2;83(21):3885-3903.e5