Sequence Detail

ID/Version

Q3T9M1 Q3U198 Q3TRN2 (UniProt | EBI)

Last sequence update: 2005-10-11
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Sphingosine-1-phosphate transporter MFSD2B {ECO:0000305};AltName: Full=Major facilitator superfamily domain-containing protein 2B {ECO:0000305}; Short=mMfsd2b {ECO:0000303|PubMed:29045386};

Provider

SWISS-PROT

Sequence

Polypeptide 494 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mfsd2b	MFSD2 lysolipid transporter B, sphingolipid	22	97	3	6

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:143949 Angers M, et al., Mfsd2a encodes a novel major facilitator superfamily domain-containing protein highly induced in brown adipose tissue during fasting and adaptive thermogenesis. Biochem J. 2008 Dec 15;416(3):347-55
J:250123 Vu TM, et al., Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets. Nature. 2017 Oct 26;550(7677):524-528
J:263093 Kobayashi N, et al., MFSD2B is a sphingosine 1-phosphate transporter in erythroid cells. Sci Rep. 2018 Mar 21;8(1):4969
J:304931 Nguyen TQ, et al., Erythrocytes efficiently utilize exogenous sphingosines for S1P synthesis and export via Mfsd2b. J Biol Chem. 2020 Dec 17;
J:317030 Chandrakanthan M, et al., Deletion of Mfsd2b impairs thrombotic functions of platelets. Nat Commun. 2021 Apr 16;12(1):2286
J:319686 Goto H, et al., Direct uptake of sphingosine-1-phosphate (S1P) independent of phospholipid phosphatases. J Biol Chem. 2021 Mar 27;:100605