Sequence Detail

ID/Version

Q3KNJ2 Q99JK0 Q9D9U0 A2RT39 (UniProt | EBI)

Last sequence update: 2005-11-08
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Non-homologous end-joining factor 1 {ECO:0000305};AltName: Full=Protein cernunnos {ECO:0000303|PubMed:17360556};AltName: Full=XRCC4-like factor {ECO:0000303|PubMed:17360556};

Provider

SWISS-PROT

Sequence

Polypeptide 295 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nhej1	non-homologous end joining factor 1	33	96	3	19

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:120145 Zha S, et al., Defective DNA repair and increased genomic instability in Cernunnos-XLF-deficient murine ES cells. Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4518-23
J:138774 Li G, et al., Lymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombination. Mol Cell. 2008 Sep 5;31(5):631-40
J:236776 Balmus G, et al., Synthetic lethality between PAXX and XLF in mammalian development. Genes Dev. 2016 Oct 1;30(19):2152-2157
J:238354 Kumar V, et al., PAXX and XLF DNA repair factors are functionally redundant in joining DNA breaks in a G1-arrested progenitor B-cell line. Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):10619-24
J:238544 Liu X, et al., PAXX promotes KU accumulation at DNA breaks and is essential for end-joining in XLF-deficient mice. Nat Commun. 2017 Jan 04;8:13816
J:265834 Hung PJ, et al., MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining. Mol Cell. 2018 Jul 19;71(2):332-342.e8
J:274050 Abramowski V, et al., PAXX and Xlf interplay revealed by impaired CNS development and immunodeficiency of double KO mice. Cell Death Differ. 2018 Feb;25(2):444-452
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89