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Sequence Detail
Q1PSW8 (UniProt | EBI) Last sequence update: 2006-05-16
Last annotation update: 2019-12-11
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RecName: Full=E3 ubiquitin-protein ligase TRIM71; EC=;AltName: Full=Protein lin-41 homolog; Short=mLin41;AltName: Full=RING-type E3 ubiquitin transferase TRIM71 {ECO:0000305};AltName: Full=Tripartite motif-containing protein 71;
Polypeptide 855 aa
For this sequence
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Orthologs Phenotypic
Gene Trim71 tripartite motif-containing 71 40 4 9 217
Sequence references in MGI J:102849 Schulman BR, et al., Reciprocal expression of lin-41 and the microRNAs let-7 and mir-125 during mouse embryogenesis. Dev Dyn. 2005 Dec;234(4):1046-54
J:102854 Lancman JJ, et al., Analysis of the regulation of lin-41 during chick and mouse limb development. Dev Dyn. 2005 Dec;234(4):948-60
J:107204 Kanamoto T, et al., Cloning and regulation of the vertebrate homologue of lin-41 that functions as a heterochronic gene in Caenorhabditis elegans. Dev Dyn. 2006 Apr;235(4):1142-9
J:152121 Maller Schulman BR, et al., The let-7 microRNA target gene, Mlin41/Trim71 is required for mouse embryonic survival and neural tube closure. Cell Cycle. 2008 Dec 15;7(24):3935-42
J:158290 Rybak A, et al., The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2. Nat Cell Biol. 2009 Dec;11(12):1411-20
J:183920 Chen J, et al., The ubiquitin ligase mLin41 temporally promotes neural progenitor cell maintenance through FGF signaling. Genes Dev. 2012 Apr 15;26(8):803-15
J:190251 Chang HM, et al., Trim71 cooperates with microRNAs to repress Cdkn1a expression and promote embryonic stem cell proliferation. Nat Commun. 2012;3:923
J:200246 Loedige I, et al., The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function. Nucleic Acids Res. 2013 Jan 7;41(1):518-32
J:226960 Cuevas E, et al., Lin41/Trim71 is essential for mouse development and specifically expressed in postnatal ependymal cells of the brain. Front Cell Dev Biol. 2015;3:20

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory