Sequence Detail

ID/Version

Q1PSW8 (UniProt | EBI)

Last sequence update: 2006-05-16
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=E3 ubiquitin-protein ligase TRIM71; EC=2.3.2.27;AltName: Full=Protein lin-41 homolog; Short=mLin41;AltName: Full=RING-type E3 ubiquitin transferase TRIM71 {ECO:0000305};AltName: Full=Tripartite motif-containing protein 71;

Provider

SWISS-PROT

Sequence

Polypeptide 855 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Trim71	tripartite motif-containing 71	33	106	3	193

Sequence references in MGI

J:102849 Schulman BR, et al., Reciprocal expression of lin-41 and the microRNAs let-7 and mir-125 during mouse embryogenesis. Dev Dyn. 2005 Dec;234(4):1046-54
J:102854 Lancman JJ, et al., Analysis of the regulation of lin-41 during chick and mouse limb development. Dev Dyn. 2005 Dec;234(4):948-60
J:107204 Kanamoto T, et al., Cloning and regulation of the vertebrate homologue of lin-41 that functions as a heterochronic gene in Caenorhabditis elegans. Dev Dyn. 2006 Apr;235(4):1142-9
J:152121 Maller Schulman BR, et al., The let-7 microRNA target gene, Mlin41/Trim71 is required for mouse embryonic survival and neural tube closure. Cell Cycle. 2008 Dec 15;7(24):3935-42
J:158290 Rybak A, et al., The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2. Nat Cell Biol. 2009 Dec;11(12):1411-20
J:183920 Chen J, et al., The ubiquitin ligase mLin41 temporally promotes neural progenitor cell maintenance through FGF signaling. Genes Dev. 2012 Apr 15;26(8):803-15
J:190251 Chang HM, et al., Trim71 cooperates with microRNAs to repress Cdkn1a expression and promote embryonic stem cell proliferation. Nat Commun. 2012;3:923
J:200246 Loedige I, et al., The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function. Nucleic Acids Res. 2013 Jan 7;41(1):518-32
J:226960 Cuevas E, et al., Lin41/Trim71 is essential for mouse development and specifically expressed in postnatal ependymal cells of the brain. Front Cell Dev Biol. 2015;3:20