Sequence Detail

ID/Version

Q0VGM9 Q5F0J8 Q6H1L2 Q6H1L1 Q6H1L0 A2AU11 A2AU12 A2AU14 Q6H1L3 Q3UM40 A2AU09 Q69ZS1 A2AU13 A2AU10 (UniProt | EBI)

Last sequence update: 2009-05-05
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Regulator of telomere elongation helicase 1 {ECO:0000255|HAMAP-Rule:MF_03065}; EC=3.6.4.12 {ECO:0000255|HAMAP-Rule:MF_03065};

Provider

SWISS-PROT

Sequence

Polypeptide 1203 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Rtel1	regulator of telomere elongation helicase 1	60	99	3	36

Sequence references in MGI

J:48933 Zhu L, et al., Telomere length regulation in mice is linked to a novel chromosome locus. Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8648-53
J:91351 Ding H, et al., Regulation of murine telomere length by Rtel: an essential gene encoding a helicase-like protein. Cell. 2004 Jun 25;117(7):873-86
J:92575 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2004 Jun 30;11(3):205-18
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:130490 Wu X, et al., Establishment of conditional knockout alleles for the gene encoding the regulator of telomere length (RTEL). Genesis. 2007 Dec;45(12):788-92
J:197762 Uringa EJ, et al., RTEL1 contributes to DNA replication and repair and telomere maintenance. Mol Biol Cell. 2012 Jul;23(14):2782-92
J:202812 Vannier JB, et al., RTEL1 is a replisome-associated helicase that promotes telomere and genome-wide replication. Science. 2013 Oct 11;342(6155):239-42
J:222674 Vannier JB, et al., RTEL1 dismantles T loops and counteracts telomeric G4-DNA to maintain telomere integrity. Cell. 2012 May 11;149(4):795-806