Sequence Detail

ID/Version

Q09XV5 Q3TV89 Q6ZPM8 Q5I1Z2 (UniProt | EBI)

Last sequence update: 2006-10-17
Last annotation update: 2026-09-02

Sequence description from provider

RecName: Full=ATP-dependent chromatin remodeler CHD8 {ECO:0000305}; EC=3.6.4.- {ECO:0000250|UniProtKB:Q9HCK8};AltName: Full=Axis duplication inhibitor; Short=Duplin;AltName: Full=Chromo domain-containing protein 8 {ECO:0000305}; Sh

Provider

SWISS-PROT

Sequence

Polypeptide 2582 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Chd8	chromodomain helicase DNA binding protein 8	115	132	3	70

Sequence references in MGI

J:86686 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Aug 31;10(4):167-80
J:92968 Nishiyama M, et al., Early embryonic death in mice lacking the beta-catenin-binding protein Duplin. Mol Cell Biol. 2004 Oct;24(19):8386-94
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:112733 Ishihara K, et al., CTCF-dependent chromatin insulator is linked to epigenetic remodeling. Mol Cell. 2006 Sep 1;23(5):733-42
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:146960 Nishiyama M, et al., CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis. Nat Cell Biol. 2009 Feb;11(2):172-82
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:383381 Kerschbamer E, et al., CHD8 suppression impacts on histone H3 lysine 36 trimethylation and alters RNA alternative splicing. Nucleic Acids Res. 2022 Dec 9;50(22):12809-12828