Sequence Detail

ID/Version

Q08874 Q08843 Q9JIJ0 Q9JKX9 Q9JIJ4 Q60781 O08885 Q9JIJ1 Q9JIJ3 Q3U2D2 O88203 Q60782 Q9JIJ5 A0A0N4SVJ5 Q9JIJ6 Q9JIJ2 (UniProt | EBI)

Last sequence update: 2017-07-05
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Microphthalmia-associated transcription factor;

Provider

SWISS-PROT

Sequence

Polypeptide 526 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mitf	melanogenesis associated transcription factor	67	146	4	56

Sequence references in MGI

J:13562 Hodgkinson CA, et al., Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein. Cell. 1993 Jul 30;74(2):395-404
J:15143 Hughes MJ, et al., A helix-loop-helix transcription factor-like gene is located at the mi locus. J Biol Chem. 1993 Oct 5;268(28):20687-90
J:21366 Steingrimsson E, et al., Molecular basis of mouse microphthalmia (mi) mutations helps explain their developmental and phenotypic consequences [see comments]. Nat Genet. 1994 Nov;8(3):256-63
J:48330 Amae S, et al., Identification of a novel isoform of microphthalmia-associated transcription factor that is enriched in retinal pigment epithelium. Biochem Biophys Res Commun. 1998 Jun 29;247(3):710-5
J:56633 Yajima I, et al., An L1 element intronic insertion in the black-eyed white (Mitf[mi-bw]) gene: the loss of a single Mitf isoform responsible for the pigmentary defect and inner ear deafness. Hum Mol Genet. 1999 Aug;8(8):1431-41
J:62098 Hallsson JH, et al., Genomic, transcriptional and mutational analysis of the mouse microphthalmia locus. Genetics. 2000 May;155(1):291-300
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:190452 Zou C, et al., Vsx2 controls eye organogenesis and retinal progenitor identity via homeodomain and non-homeodomain residues required for high affinity DNA binding. PLoS Genet. 2012 Sep;8(9):e1002924
J:191195 Pogenberg V, et al., Restricted leucine zipper dimerization and specificity of DNA recognition of the melanocyte master regulator MITF. Genes Dev. 2012 Dec 1;26(23):2647-58
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89