Sequence Detail

ID/Version

Q08369 Q9QZK4 B9EHF7 P97491 (UniProt | EBI)

Last sequence update: 2014-03-19
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=Transcription factor GATA-4;AltName: Full=GATA-binding factor 4;

Provider

SWISS-PROT

Sequence

Polypeptide 441 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Gata4	GATA binding protein 4	175	311	3	32

Sequence references in MGI

J:4641 Arceci RJ, et al., Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart. Mol Cell Biol. 1993 Apr;13(4):2235-46
J:93176 Molkentin JD, et al., A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell. 1998 May 17;93(2):215-28
J:95125 Kim TG, et al., Jumonji represses atrial natriuretic factor gene expression by inhibiting transcriptional activities of cardiac transcription factors. Mol Cell Biol. 2004 Dec;24(23):10151-60
J:101354 Rath N, et al., LMCD1/Dyxin is a novel transcriptional cofactor that restricts GATA6 function by inhibiting DNA binding. Mol Cell Biol. 2005 Oct;25(20):8864-73
J:124772 Farin HF, et al., Transcriptional Repression by the T-box Proteins Tbx18 and Tbx15 Depends on Groucho Corepressors. J Biol Chem. 2007 Aug 31;282(35):25748-59
J:166035 Lee Y, et al., The cardiac tissue-restricted homeobox protein Csx/Nkx2.5 physically associates with the zinc finger protein GATA4 and cooperatively activates atrial natriuretic factor gene expression. Mol Cell Biol. 1998 Jun;18(6):3120-9
J:179371 He A, et al., PRC2 directly methylates GATA4 and represses its transcriptional activity. Genes Dev. 2012 Jan 1;26(1):37-42
J:322763 Gonzalez-Teran B, et al., Transcription factor protein interactomes reveal genetic determinants in heart disease. Cell. 2022 Mar 3;185(5):794-814.e30