Sequence Detail

ID/Version

Q08351 A6H8H6 Q8BRX0 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Thrombopoietin receptor; Short=TPO-R;AltName: Full=Myeloproliferative leukemia protein;AltName: Full=Proto-oncogene c-Mpl;AltName: CD_antigen=CD110;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 625 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mpl	myeloproliferative leukemia virus oncogene	38	124	3	18

Sequence references in MGI

J:12827 Skoda RC, et al., Murine c-mpl: a member of the hematopoietic growth factor receptor superfamily that transduces a proliferative signal. EMBO J. 1993 Jul;12(7):2645-53
J:14725 Vigon I, et al., Characterization of the murine Mpl proto-oncogene, a member of the hematopoietic cytokine receptor family: molecular cloning, chromosomal location and evidence for a function in cell growth. Oncogene. 1993 Oct;8(10):2607-15
J:32131 Alexander WS, et al., Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl. Blood. 1996 Mar 15;87(6):2162-70
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:261836 Xiao N, et al., Ott1 (Rbm15) regulates thrombopoietin response in hematopoietic stem cells through alternative splicing of c-Mpl. Blood. 2015 Feb 5;125(6):941-8